Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7016" target="_blank" >RIV/00064203:_____/11:7016 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/11:00370885 RIV/00216208:11130/11:7016

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21124005" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21124005</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment

Popis výsledku v původním jazyce

Background: The effect of APOE epsilon 4 allele (epsilon 4) on spatial navigation in amnestic mild cognitive impairment (aMCI) is unknown. Objective: Our purpose was to examine the characteristics of spatial navigation impairment in epsilon 4-positive (epsilon 4+) and epsilon 4-negative (epsilon 4-) aMCI subgroups. Methods: Blood samples were collected to determine the APOE genotype. A total of 34 aMCI patients were stratified into aMCI-epsilon 4- (n = 23) and aMCI-epsilon 4+ (n = 11) groups. Control (n= 28) and mild Alzheimer's disease (AD; n = 16) groups were also used. We used a human analogue of the Morris water maze (enclosed arena 2.9 m in diameter) to examine body-centered (egocentric) and world-centered (allocentric) spatial navigation. Results: The aMCI-epsilon 4+ group performed poorer on spatial navigation than the aMCI-epsilon 4-group in both egocentric and allocentric tasks even though these 2 groups did not differ in global cognitive functioning or neuropsychological tes

Název v anglickém jazyce

Spatial Navigation and APOE in Amnestic Mild Cognitive Impairment

Popis výsledku anglicky

Background: The effect of APOE epsilon 4 allele (epsilon 4) on spatial navigation in amnestic mild cognitive impairment (aMCI) is unknown. Objective: Our purpose was to examine the characteristics of spatial navigation impairment in epsilon 4-positive (epsilon 4+) and epsilon 4-negative (epsilon 4-) aMCI subgroups. Methods: Blood samples were collected to determine the APOE genotype. A total of 34 aMCI patients were stratified into aMCI-epsilon 4- (n = 23) and aMCI-epsilon 4+ (n = 11) groups. Control (n= 28) and mild Alzheimer's disease (AD; n = 16) groups were also used. We used a human analogue of the Morris water maze (enclosed arena 2.9 m in diameter) to examine body-centered (egocentric) and world-centered (allocentric) spatial navigation. Results: The aMCI-epsilon 4+ group performed poorer on spatial navigation than the aMCI-epsilon 4-group in both egocentric and allocentric tasks even though these 2 groups did not differ in global cognitive functioning or neuropsychological tes

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurodegenerative Diseases

ISSN

1660-2854

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

169-177

Kód UT WoS článku

000290559000002

EID výsledku v databázi Scopus

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