Proteomic analysis of the plasma samples of patients with stable angina pectoris

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8391" target="_blank" >RIV/00064203:_____/12:8391 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023736:_____/12:00009613 RIV/00216208:11130/12:8391

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.crvasa.2012.01.006" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2012.01.006</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Proteomic analysis of the plasma samples of patients with stable angina pectoris

Popis výsledku v původním jazyce

In this study, the results of the proteomic analysis of plasma samples of stable angina patients are presented. Background: Plasma samples from 44 patients were analysed in two groups: (A) a control group of 22 patients without significant coronary artery disease and (B) 22 patients admitted with stable angina pectoris. Methods: During coronary angiography, plasma samples were collected and further analysed using two-dimensional gel electrophoresis, image analysis and mass spectrometry. Results: Five spots were found with significantly increased or decreased normalised volumes resulting from either a change in the amount of protein or changes in posttranslational modifications. Spots containing serum amyloid A protein and fibrinogen gamma chains displayed increased normalised volumes, and spots containing apoliprotein A-1 and pigment epithelium derived factor showed decreased normalised volumes. Conclusions: Almost identical proteomic profiles of the stable angina pectoris group compar

Název v anglickém jazyce

Proteomic analysis of the plasma samples of patients with stable angina pectoris

Popis výsledku anglicky

In this study, the results of the proteomic analysis of plasma samples of stable angina patients are presented. Background: Plasma samples from 44 patients were analysed in two groups: (A) a control group of 22 patients without significant coronary artery disease and (B) 22 patients admitted with stable angina pectoris. Methods: During coronary angiography, plasma samples were collected and further analysed using two-dimensional gel electrophoresis, image analysis and mass spectrometry. Results: Five spots were found with significantly increased or decreased normalised volumes resulting from either a change in the amount of protein or changes in posttranslational modifications. Spots containing serum amyloid A protein and fibrinogen gamma chains displayed increased normalised volumes, and spots containing apoliprotein A-1 and pigment epithelium derived factor showed decreased normalised volumes. Conclusions: Almost identical proteomic profiles of the stable angina pectoris group compar

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

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Svazek periodika

54

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

"e22"-"e26"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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