Peripheral neuropathy in Whipple?s disease: A case report

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8439" target="_blank" >RIV/00064203:_____/12:8439 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/12:8439 RIV/00064190:_____/12:#0000322

Výsledek na webu

<a href="http://www.cspatologie.cz/docs/481-abstraktCZ.pdf" target="_blank" >http://www.cspatologie.cz/docs/481-abstraktCZ.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Peripheral neuropathy in Whipple?s disease: A case report

Popis výsledku v původním jazyce

Whipple?s disease is a chronic multisystem inflammatory disease with predominantly gastrointestinal manifestations due to Tropheryma whipplei infection. Typical neurological abnormalities include dementia, eye movement abnormalities, hypothalamic dysfunction and oculomasticatory myorhythmias. The literature on peripheral neuropathy in Whipple?s disease is sparse and the involvement of peripheral nerves in Whipple?s disease has not been documented convincingly so far. We present a case of Whipple?s disease presenting by axonal peripheral neuropathy without gastrointestinal involvement. The diagnosis was confirmed by a sural nerve biopsy and consequent PCR of the sample. All clinical signs disappeared progressively during the antibiotic therapy. Two years after the T. whipplei infection, the patient developed dopa-sensitive Parkinson?s disease, although these two events seem to be unrelated. This case illustrates the value of peripheral nerve biopsy

Název v anglickém jazyce

Peripheral neuropathy in Whipple?s disease: A case report

Popis výsledku anglicky

Whipple?s disease is a chronic multisystem inflammatory disease with predominantly gastrointestinal manifestations due to Tropheryma whipplei infection. Typical neurological abnormalities include dementia, eye movement abnormalities, hypothalamic dysfunction and oculomasticatory myorhythmias. The literature on peripheral neuropathy in Whipple?s disease is sparse and the involvement of peripheral nerves in Whipple?s disease has not been documented convincingly so far. We present a case of Whipple?s disease presenting by axonal peripheral neuropathy without gastrointestinal involvement. The diagnosis was confirmed by a sural nerve biopsy and consequent PCR of the sample. All clinical signs disappeared progressively during the antibiotic therapy. Two years after the T. whipplei infection, the patient developed dopa-sensitive Parkinson?s disease, although these two events seem to be unrelated. This case illustrates the value of peripheral nerve biopsy

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česko-slovenská patologie a soudní lékařství

ISSN

1210-7875

e-ISSN

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Svazek periodika

48-57

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

97-99

Kód UT WoS článku

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EID výsledku v databázi Scopus

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