Treatment Options for Children with Monogenic Forms of Obesity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F13%3A10209826" target="_blank" >RIV/00064203:_____/13:10209826 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/13:10209826 RIV/00023761:_____/13:#0000387 RIV/00216208:11120/13:43907257

Výsledek na webu

<a href="http://www.karger.com/Article/FullText/342556" target="_blank" >http://www.karger.com/Article/FullText/342556</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Treatment Options for Children with Monogenic Forms of Obesity

Popis výsledku v původním jazyce

Mutations in genes involved in energy balance regulation within the central nervous system lead to monogenic forms of obesities. Individuals with these mutations are characterized by early-onset obesity and in some cases by endocrine abnormalities. Carriers of leptin gene mutations are able to normalize their body weight after daily subcutaneous leptin administration. Pharmacotherapy targeting the specific-gene deficiencies has not clinically been tested in other monogenic obesities. Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common monogenic cause of human obesity. Several treatment options have been investigated in subjects with MC4R mutations. Few studies showed that an intensive life-style intervention induces similar weight reduction in MC4R mutation carriers in comparison to MC4R mutation noncarriers. However, long-term body weight maintenance is hardly ever achieved in MC4R mutation carriers. Sibutramine, serotonin and noradrenalin reuptake inhibitor

Název v anglickém jazyce

Treatment Options for Children with Monogenic Forms of Obesity

Popis výsledku anglicky

Mutations in genes involved in energy balance regulation within the central nervous system lead to monogenic forms of obesities. Individuals with these mutations are characterized by early-onset obesity and in some cases by endocrine abnormalities. Carriers of leptin gene mutations are able to normalize their body weight after daily subcutaneous leptin administration. Pharmacotherapy targeting the specific-gene deficiencies has not clinically been tested in other monogenic obesities. Mutations in the melanocortin 4 receptor gene (MC4R) represent the most common monogenic cause of human obesity. Several treatment options have been investigated in subjects with MC4R mutations. Few studies showed that an intensive life-style intervention induces similar weight reduction in MC4R mutation carriers in comparison to MC4R mutation noncarriers. However, long-term body weight maintenance is hardly ever achieved in MC4R mutation carriers. Sibutramine, serotonin and noradrenalin reuptake inhibitor

Druh

D - Stať ve sborníku

CEP obor

FG - Pediatrie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12342" target="_blank" >NT12342: Výživa, obezita a metabolický syndrom u dětí a dospívajících - vliv na metabolizmus lipidů a adipokinů, změny při redukčním režimu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

World review of nutrition and dietetics

ISBN

978-3-318-02265-0

ISSN

0084-2230

e-ISSN

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Počet stran výsledku

8

Strana od-do

105-112

Název nakladatele

KARGER

Místo vydání

BASEL

Místo konání akce

Paris

Datum konání akce

1. 3. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000316645700016