Epithelial basement membrane thickening is related to TGF-Beta 1 expression in children with chronic respiratory diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293145" target="_blank" >RIV/00064203:_____/14:10293145 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/14:10293145
Výsledek na webu
<a href="http://dx.doi.org/10.1111/pai.12275" target="_blank" >http://dx.doi.org/10.1111/pai.12275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pai.12275" target="_blank" >10.1111/pai.12275</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Epithelial basement membrane thickening is related to TGF-Beta 1 expression in children with chronic respiratory diseases
Popis výsledku v původním jazyce
BackgroundThe complex structural changes of bronchial mucosa, known as remodelling, have been considered unique and typical for asthma. However, similar changes were recently found in other chronic respiratory diseases. The aim of this study was to compare basement membrane (BM) thickness and the number of transforming growth factor beta 1 (TGF-1) positive epithelial cells in children with asthma, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and healthy controls. MethodsA total of 58 children(11.13.9yr, 55% males) were enrolled in this cross-sectional study. Endobronchial biopsy was performed in 27 children with asthma, 12 with CF, 12 with PCD and in 7 control patients. We studied the samples using light microscopy to assess BM width, the number of TGF-1 positive epithelial cells and their correlation. ResultsWe found increased BM thickness (6.65 +/- 1.22m vs. 2.93 +/- 0.75m, p<0.01) and a higher number of TGF-1 positive epithelial cells (61.39 +/- 19.03 vs. 21.57 +/- 12.58,
Název v anglickém jazyce
Epithelial basement membrane thickening is related to TGF-Beta 1 expression in children with chronic respiratory diseases
Popis výsledku anglicky
BackgroundThe complex structural changes of bronchial mucosa, known as remodelling, have been considered unique and typical for asthma. However, similar changes were recently found in other chronic respiratory diseases. The aim of this study was to compare basement membrane (BM) thickness and the number of transforming growth factor beta 1 (TGF-1) positive epithelial cells in children with asthma, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and healthy controls. MethodsA total of 58 children(11.13.9yr, 55% males) were enrolled in this cross-sectional study. Endobronchial biopsy was performed in 27 children with asthma, 12 with CF, 12 with PCD and in 7 control patients. We studied the samples using light microscopy to assess BM width, the number of TGF-1 positive epithelial cells and their correlation. ResultsWe found increased BM thickness (6.65 +/- 1.22m vs. 2.93 +/- 0.75m, p<0.01) and a higher number of TGF-1 positive epithelial cells (61.39 +/- 19.03 vs. 21.57 +/- 12.58,
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FG - Pediatrie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT11444" target="_blank" >NT11444: Časné projevy průduškového astmatu u dětí - funkční a morfologické důsledky nemoci</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Pediatric Allergy and Immunology
ISSN
0905-6157
e-ISSN
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Svazek periodika
25
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
DK - Dánské království
Počet stran výsledku
7
Strana od-do
593-599
Kód UT WoS článku
000344872400011
EID výsledku v databázi Scopus
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