Obstruction after alcohol septal ablation is associated with cardiovascular mortality events

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10332735" target="_blank" >RIV/00064203:_____/16:10332735 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00091205 RIV/00216208:11130/16:10332735 RIV/00159816:_____/16:00065578

Výsledek na webu

<a href="http://dx.doi.org/10.1136/heartjnl-2016-309699" target="_blank" >http://dx.doi.org/10.1136/heartjnl-2016-309699</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/heartjnl-2016-309699" target="_blank" >10.1136/heartjnl-2016-309699</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Obstruction after alcohol septal ablation is associated with cardiovascular mortality events

Popis výsledku v původním jazyce

Background Left ventricular outflow tract obstruction (>= 30 mm Hg at rest; LVOTO) is considered a possible risk of long-term outcomes in patients with hypertrophic cardiomyopathy (HCM). However, the influence of LVOTO on the occurrence of cardiovascular mortality events in patients after alcohol septal ablation (ASA) for obstructive HCM remains unresolved. Methods We compared the outcomes of patients treated with ASA with residual LVOTO < 30 mm Hg with those with residual LVOTO >= 30 mm Hg at the first postdischarge check-up (1-6 months after the procedure). Results A total of 270 patients (60 +/- 12 years, median follow-up 5.1 years; 95% CI 4.5 to 5.9 years) treated with a single ASA were included; 208 (77%) and 62 (23%) patients had post-ASA LVOTO < 30 and >= 30 mm Hg at the first postdischarge clinical check-up, respectively (LVOTO 13 +/- 6 vs 50 +/- 27 mm Hg; p<0.01). Freedom from cardiovascular mortality events at 1, 5 and 10 years were 99% (95% CI 96% to 100%) vs 94% (95% CI 85% to 98%), 95% (95% CI 89% to 97%) vs 80% (95% CI 66% to 89%) and 82% (95% CI 69% to 89%) vs 72% (95% CI 55% to 84%) (log-rank test, p<0.01), respectively. In multivariable analysis adjusted for age at ASA, sex, baseline LVOTO and baseline septum thickness, the independent predictors of cardiovascular mortality events were early postdischarge LVOTO >= 30 mm Hg (HR 2.95, 95% CI 1.26 to 6.91; p=0.01) and baseline septum thickness (HR 1.07, 95% CI 1.01 to 1.13; p=0.02). Conclusions After ASA for obstructive HCM, LVOTO >= 30 mm Hg at the first postdischarge clinical check-up is associated with significantly higher occurrence of subsequent cardiovascular mortality events.

Název v anglickém jazyce

Obstruction after alcohol septal ablation is associated with cardiovascular mortality events

Popis výsledku anglicky

Background Left ventricular outflow tract obstruction (>= 30 mm Hg at rest; LVOTO) is considered a possible risk of long-term outcomes in patients with hypertrophic cardiomyopathy (HCM). However, the influence of LVOTO on the occurrence of cardiovascular mortality events in patients after alcohol septal ablation (ASA) for obstructive HCM remains unresolved. Methods We compared the outcomes of patients treated with ASA with residual LVOTO < 30 mm Hg with those with residual LVOTO >= 30 mm Hg at the first postdischarge check-up (1-6 months after the procedure). Results A total of 270 patients (60 +/- 12 years, median follow-up 5.1 years; 95% CI 4.5 to 5.9 years) treated with a single ASA were included; 208 (77%) and 62 (23%) patients had post-ASA LVOTO < 30 and >= 30 mm Hg at the first postdischarge clinical check-up, respectively (LVOTO 13 +/- 6 vs 50 +/- 27 mm Hg; p<0.01). Freedom from cardiovascular mortality events at 1, 5 and 10 years were 99% (95% CI 96% to 100%) vs 94% (95% CI 85% to 98%), 95% (95% CI 89% to 97%) vs 80% (95% CI 66% to 89%) and 82% (95% CI 69% to 89%) vs 72% (95% CI 55% to 84%) (log-rank test, p<0.01), respectively. In multivariable analysis adjusted for age at ASA, sex, baseline LVOTO and baseline septum thickness, the independent predictors of cardiovascular mortality events were early postdischarge LVOTO >= 30 mm Hg (HR 2.95, 95% CI 1.26 to 6.91; p=0.01) and baseline septum thickness (HR 1.07, 95% CI 1.01 to 1.13; p=0.02). Conclusions After ASA for obstructive HCM, LVOTO >= 30 mm Hg at the first postdischarge clinical check-up is associated with significantly higher occurrence of subsequent cardiovascular mortality events.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/NV15-34904A" target="_blank" >NV15-34904A: Sekvenování nové generace k určení časné diagnózy a individualizované léčby hypertrofické kardiomyopatie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart

ISSN

1355-6037

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

22

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

1793-1796

Kód UT WoS článku

000387065200007

EID výsledku v databázi Scopus

2-s2.0-84984972832