Outcomes of Alcohol Septal Ablation in Patients with Severe Left Ventricular Outflow Tract Obstruction: A Propensity Score Matching Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10465380" target="_blank" >RIV/00064203:_____/23:10465380 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10465380 RIV/00216208:11310/23:10465380

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9iU63gbzZ5" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9iU63gbzZ5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cjca.2023.06.417" target="_blank" >10.1016/j.cjca.2023.06.417</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Outcomes of Alcohol Septal Ablation in Patients with Severe Left Ventricular Outflow Tract Obstruction: A Propensity Score Matching Analysis

Popis výsledku v původním jazyce

BACKGROUND: The current ACC/AHA guidelines on hypertrophic cardiomyopathy (HCM) caution that alcohol septal ablation (ASA) might be less effective in patients with left ventricular outflow tract obstruction (LVOTO) &gt;=100 mmHg.METHODS: We used a multinational registry to evaluate the outcome of ASA patients according to baseline LVOTO.RESULTS: A total of 1346 ASA patients were enrolled and followed for 5.8+-4.7 years (7764 patient-years). The patients with baseline LVOTO &gt;=100 mmHg were significantly older (61+-14 years vs. 57+-13 years; p&lt;0.01), more often women (60% vs. 45%; p&lt;0.01), and had a more pronounced HCM phenotype than those with baseline LVOTO &lt;100 mmHg. There were no significant differences in the occurrences of 30-day major cardiovascular adverse events in the two groups. After propensity score matching (2 groups, 257 pairs of patients), the long-term survival was similar in both groups (p=0.10), the relative reduction of LVOTO was higher in the group with the baseline LVOTO &gt;=100 mmHg (82+-21% vs. 73+-26%; p&lt;0.01), but the residual resting LVOTO remained higher in this group (23+-29 mmHg vs. 13+-13 mmHg; p&lt;0.01). Dyspnea (NYHA class) at the most recent clinical check-up was similar in both groups (1.7+-0.7 vs. 1.7+-0.7; p=0.85), and patients with baseline LVOTO &gt;=100 mmHg underwent more re-interventions (p=0.02).CONCLUSIONS: After propensity matching, ASA patients with baseline LVOTO &gt;=100 mmHg had similar survival and dyspnea (NYHA class) as patients with baseline LVOTO &lt;100 mmHg but their residual LVOTO and risk of repeated procedures were higher.

Název v anglickém jazyce

Outcomes of Alcohol Septal Ablation in Patients with Severe Left Ventricular Outflow Tract Obstruction: A Propensity Score Matching Analysis

Popis výsledku anglicky

BACKGROUND: The current ACC/AHA guidelines on hypertrophic cardiomyopathy (HCM) caution that alcohol septal ablation (ASA) might be less effective in patients with left ventricular outflow tract obstruction (LVOTO) &gt;=100 mmHg.METHODS: We used a multinational registry to evaluate the outcome of ASA patients according to baseline LVOTO.RESULTS: A total of 1346 ASA patients were enrolled and followed for 5.8+-4.7 years (7764 patient-years). The patients with baseline LVOTO &gt;=100 mmHg were significantly older (61+-14 years vs. 57+-13 years; p&lt;0.01), more often women (60% vs. 45%; p&lt;0.01), and had a more pronounced HCM phenotype than those with baseline LVOTO &lt;100 mmHg. There were no significant differences in the occurrences of 30-day major cardiovascular adverse events in the two groups. After propensity score matching (2 groups, 257 pairs of patients), the long-term survival was similar in both groups (p=0.10), the relative reduction of LVOTO was higher in the group with the baseline LVOTO &gt;=100 mmHg (82+-21% vs. 73+-26%; p&lt;0.01), but the residual resting LVOTO remained higher in this group (23+-29 mmHg vs. 13+-13 mmHg; p&lt;0.01). Dyspnea (NYHA class) at the most recent clinical check-up was similar in both groups (1.7+-0.7 vs. 1.7+-0.7; p=0.85), and patients with baseline LVOTO &gt;=100 mmHg underwent more re-interventions (p=0.02).CONCLUSIONS: After propensity matching, ASA patients with baseline LVOTO &gt;=100 mmHg had similar survival and dyspnea (NYHA class) as patients with baseline LVOTO &lt;100 mmHg but their residual LVOTO and risk of repeated procedures were higher.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Canadian Journal of Cardiology

ISSN

0828-282X

e-ISSN

1916-7075

Svazek periodika

39

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1622-1629

Kód UT WoS článku

001111502700001

EID výsledku v databázi Scopus

2-s2.0-85173219425