Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F16%3A10337222" target="_blank" >RIV/00064203:_____/16:10337222 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/16:10337222

Výsledek na webu

<a href="http://dx.doi.org/10.1038/nn.4228" target="_blank" >http://dx.doi.org/10.1038/nn.4228</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/nn.4228" target="_blank" >10.1038/nn.4228</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Popis výsledku v původním jazyce

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Název v anglickém jazyce

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Popis výsledku anglicky

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nature Neuroscience

ISSN

1097-6256

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

420-431

Kód UT WoS článku

000370822200014

EID výsledku v databázi Scopus

2-s2.0-84959158225