Analysis of shared heritability in common disorders of the brain
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376916" target="_blank" >RIV/00216208:11110/18:10376916 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023752:_____/18:43919405 RIV/00064165:_____/18:10376916
Výsledek na webu
<a href="https://doi.org/10.1126/science.aap8757" target="_blank" >https://doi.org/10.1126/science.aap8757</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.aap8757" target="_blank" >10.1126/science.aap8757</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Analysis of shared heritability in common disorders of the brain
Popis výsledku v původním jazyce
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Název v anglickém jazyce
Analysis of shared heritability in common disorders of the brain
Popis výsledku anglicky
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30215 - Psychiatry
Návaznosti výsledku
Projekt
—
Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Science
ISSN
0036-8075
e-ISSN
—
Svazek periodika
360
Číslo periodika v rámci svazku
6395
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
13
Strana od-do
—
Kód UT WoS článku
000436040600034
EID výsledku v databázi Scopus
2-s2.0-85049284114