Severe Acute Heart Failure - Experimental Model With Very Low Mortality
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F18%3A10427544" target="_blank" >RIV/00064203:_____/18:10427544 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/18:10378637 RIV/00023884:_____/18:00007936
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iF1Xj.tWL8" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=iF1Xj.tWL8</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Severe Acute Heart Failure - Experimental Model With Very Low Mortality
Popis výsledku v původním jazyce
The growth in the experimental research of facilities to support extracorporeal circulation requires the further development of models of acute heart failure that can be well controlled and reproduced. Two types of acute heart failure were examined in domestic pigs (Sus scrofa domestica): a hypoxic model (n=5) with continuous perfusion of the left coronary artery by hypoxic deoxygenated blood and ischemic model (n=9) with proximal closure of the left coronary artery and controlled hypoperfusion behind the closure. The aim was a severe, stable heart pump failure defined by hemodynamic parameters changes: a) decrease in cardiac output by at least 50 %; b) decrease in mixed venous blood saturation to under 60 %; c) left ventricular ejection fraction below 25 %; and d) decrease in flow via the carotid arteries at least 50 %. Acute heart failure developed in the first group in one animal with no acute mortality and in the second group in 8 animals with no acute mortality. In the case of ischemic model the cardiac output fell from 6.70 +/- 0.89 l/min to 2.89 +/- 0.75 <b>l/min. The saturation of the mixed venous blood decreased from 83 +/- 2 % to 58 +/- 8 %. The left ventricular ejection fraction decreased from 50 +/- 8 % to 19 +/- 2 %. The flow via the carotid arteries decreased from 337 +/- 78 ml/min to 136 +/- 59 ml/min (P <= 0.001 for all comparisons). The proposed ischemic model is not burdened with acute mortality in the development of heart failure and is suitable for further use in experimental research into extracorporeal circulatory support.
Název v anglickém jazyce
Severe Acute Heart Failure - Experimental Model With Very Low Mortality
Popis výsledku anglicky
The growth in the experimental research of facilities to support extracorporeal circulation requires the further development of models of acute heart failure that can be well controlled and reproduced. Two types of acute heart failure were examined in domestic pigs (Sus scrofa domestica): a hypoxic model (n=5) with continuous perfusion of the left coronary artery by hypoxic deoxygenated blood and ischemic model (n=9) with proximal closure of the left coronary artery and controlled hypoperfusion behind the closure. The aim was a severe, stable heart pump failure defined by hemodynamic parameters changes: a) decrease in cardiac output by at least 50 %; b) decrease in mixed venous blood saturation to under 60 %; c) left ventricular ejection fraction below 25 %; and d) decrease in flow via the carotid arteries at least 50 %. Acute heart failure developed in the first group in one animal with no acute mortality and in the second group in 8 animals with no acute mortality. In the case of ischemic model the cardiac output fell from 6.70 +/- 0.89 l/min to 2.89 +/- 0.75 <b>l/min. The saturation of the mixed venous blood decreased from 83 +/- 2 % to 58 +/- 8 %. The left ventricular ejection fraction decreased from 50 +/- 8 % to 19 +/- 2 %. The flow via the carotid arteries decreased from 337 +/- 78 ml/min to 136 +/- 59 ml/min (P <= 0.001 for all comparisons). The proposed ischemic model is not burdened with acute mortality in the development of heart failure and is suitable for further use in experimental research into extracorporeal circulatory support.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
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OECD FORD obor
30105 - Physiology (including cytology)
Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
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Svazek periodika
67
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
555-562
Kód UT WoS článku
000442016100004
EID výsledku v databázi Scopus
2-s2.0-85051604267