Severe Acute Heart Failure - Experimental Model With Very Low Mortality

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10378637" target="_blank" >RIV/00216208:11110/18:10378637 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/18:00007936 RIV/00064203:_____/18:10427544

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/67/67_555.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/67/67_555.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Severe Acute Heart Failure - Experimental Model With Very Low Mortality

Popis výsledku v původním jazyce

The growth in the experimental research of facilities to support extracorporeal circulation requires the further development of models of acute heart failure that can be well controlled and reproduced. Two types of acute heart failure were examined in domestic pigs (Sus scrofa domestica): a hypoxic model (n=5) with continuous perfusion of the left coronary artery by hypoxic deoxygenated blood and ischemic model (n=9) with proximal closure of the left coronary artery and controlled hypoperfusion behind the closure. The aim was a severe, stable heart pump failure defined by hemodynamic parameters changes: a) decrease in cardiac output by at least 50 %; b) decrease in mixed venous blood saturation to under 60 %; c) left ventricular ejection fraction below 25 %; and d) decrease in flow via the carotid arteries at least 50 %. Acute heart failure developed in the first group in one animal with no acute mortality and in the second group in 8 animals with no acute mortality. In the case of ischemic model the cardiac output fell from 6.70 +/- 0.89 l/min to 2.89 +/- 0.75 &lt;b&gt;l/min. The saturation of the mixed venous blood decreased from 83 +/- 2 % to 58 +/- 8 %. The left ventricular ejection fraction decreased from 50 +/- 8 % to 19 +/- 2 %. The flow via the carotid arteries decreased from 337 +/- 78 ml/min to 136 +/- 59 ml/min (P &lt;= 0.001 for all comparisons). The proposed ischemic model is not burdened with acute mortality in the development of heart failure and is suitable for further use in experimental research into extracorporeal circulatory support.

Název v anglickém jazyce

Severe Acute Heart Failure - Experimental Model With Very Low Mortality

Popis výsledku anglicky

The growth in the experimental research of facilities to support extracorporeal circulation requires the further development of models of acute heart failure that can be well controlled and reproduced. Two types of acute heart failure were examined in domestic pigs (Sus scrofa domestica): a hypoxic model (n=5) with continuous perfusion of the left coronary artery by hypoxic deoxygenated blood and ischemic model (n=9) with proximal closure of the left coronary artery and controlled hypoperfusion behind the closure. The aim was a severe, stable heart pump failure defined by hemodynamic parameters changes: a) decrease in cardiac output by at least 50 %; b) decrease in mixed venous blood saturation to under 60 %; c) left ventricular ejection fraction below 25 %; and d) decrease in flow via the carotid arteries at least 50 %. Acute heart failure developed in the first group in one animal with no acute mortality and in the second group in 8 animals with no acute mortality. In the case of ischemic model the cardiac output fell from 6.70 +/- 0.89 l/min to 2.89 +/- 0.75 &lt;b&gt;l/min. The saturation of the mixed venous blood decreased from 83 +/- 2 % to 58 +/- 8 %. The left ventricular ejection fraction decreased from 50 +/- 8 % to 19 +/- 2 %. The flow via the carotid arteries decreased from 337 +/- 78 ml/min to 136 +/- 59 ml/min (P &lt;= 0.001 for all comparisons). The proposed ischemic model is not burdened with acute mortality in the development of heart failure and is suitable for further use in experimental research into extracorporeal circulatory support.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

67

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

555-562

Kód UT WoS článku

000442016100004

EID výsledku v databázi Scopus

2-s2.0-85051604267