Comparison of interim PET response to second-line vs. to first-line treatment in classical Hodgkin lymphoma - contribution to the development of response criteria for relapsed or progressive disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10413221" target="_blank" >RIV/00064203:_____/21:10413221 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/21:10413221

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=w2Tvru4HUL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=w2Tvru4HUL</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2967/jnumed.120.247924" target="_blank" >10.2967/jnumed.120.247924</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of interim PET response to second-line vs. to first-line treatment in classical Hodgkin lymphoma - contribution to the development of response criteria for relapsed or progressive disease

Popis výsledku v původním jazyce

Rationale: In first-line treatment of Hodgkin lymphoma (HL) Deauville scores 1-3 define complete metabolic remission. Interim FDG-PET is also used for relapse treatment adaptation, however PET-response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early treatment response to first-line and to second-line treatment in 127 patients with classical Hodgkin lymphoma who experienced relapse. Patients participated in the prospective, multicenter EuroNet-PHL-C1 study. Residual uptake was measured retrospectively using the qPET method, a validated semiautomatic quantitative extension of the Deauville score. Empirical cumulative distribution functions (ECDF) of the qPET values were used to systematically analyze the response to first-line and second-line treatment. Results and Conclusion: Individual patients responded variably to first-line and second line treatment. However, the ECDF of the qPET values from all patients were nearly superimposable. This supports that first-line and second-line treatment in HL do not require different response criteria.

Název v anglickém jazyce

Comparison of interim PET response to second-line vs. to first-line treatment in classical Hodgkin lymphoma - contribution to the development of response criteria for relapsed or progressive disease

Popis výsledku anglicky

Rationale: In first-line treatment of Hodgkin lymphoma (HL) Deauville scores 1-3 define complete metabolic remission. Interim FDG-PET is also used for relapse treatment adaptation, however PET-response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early treatment response to first-line and to second-line treatment in 127 patients with classical Hodgkin lymphoma who experienced relapse. Patients participated in the prospective, multicenter EuroNet-PHL-C1 study. Residual uptake was measured retrospectively using the qPET method, a validated semiautomatic quantitative extension of the Deauville score. Empirical cumulative distribution functions (ECDF) of the qPET values were used to systematically analyze the response to first-line and second-line treatment. Results and Conclusion: Individual patients responded variably to first-line and second line treatment. However, the ECDF of the qPET values from all patients were nearly superimposable. This supports that first-line and second-line treatment in HL do not require different response criteria.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nuclear Medicine

ISSN

0161-5505

e-ISSN

—

Svazek periodika

62

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

338-341

Kód UT WoS článku

000621328300009

EID výsledku v databázi Scopus

2-s2.0-85102217914