Current management in the treatment of intramedullary ependymomas in children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F23%3A10452774" target="_blank" >RIV/00064203:_____/23:10452774 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/23:00001299 RIV/00216208:11130/23:10452774 RIV/00216208:11110/23:10452774

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=37uETSPoG" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=37uETSPoG</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00381-022-05814-y" target="_blank" >10.1007/s00381-022-05814-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Current management in the treatment of intramedullary ependymomas in children

Popis výsledku v původním jazyce

Purpose: Current management of pediatric intramedullary ependymoma is extrapolated from adult series since large studies in children are unavailable. This has led us to share our experience with this rare tumor and compare it to the literature and to review and highlight important aspects of current management and point out inconsistencies. Methods: This is a retrospective analysis of patients with intramedullary ependymoma managed at our institution between 2004 and 2021. Results: During the study period, 5 patients were treated for intramedullary ependymoma. Cases of myxopapillary ependymoma were excluded. The mean age of our cohort was 11.2 years. We identified 4 cases of grade II ependymoma and 1 case of grade III ependymoma. Gross tumor removal (GTR) was achieved in two patients (40%) of patients. One patient was treated with radiotherapy for recurrence and two patients received chemotherapy. There were no cases of recurrence among patients treated with GTR, but in all patients treated with STR. Eighty percent of patients either improved or stayed stable neurologically. During follow-up (mean 73 months), 2 patients died of disease. Conclusion: GTR and tumor grade remain the key prognostic factor of long-term tumor-free survival. Many questions prevail regarding outcomes, correct use of adjuvant therapy, and prognostic factors.

Název v anglickém jazyce

Current management in the treatment of intramedullary ependymomas in children

Popis výsledku anglicky

Purpose: Current management of pediatric intramedullary ependymoma is extrapolated from adult series since large studies in children are unavailable. This has led us to share our experience with this rare tumor and compare it to the literature and to review and highlight important aspects of current management and point out inconsistencies. Methods: This is a retrospective analysis of patients with intramedullary ependymoma managed at our institution between 2004 and 2021. Results: During the study period, 5 patients were treated for intramedullary ependymoma. Cases of myxopapillary ependymoma were excluded. The mean age of our cohort was 11.2 years. We identified 4 cases of grade II ependymoma and 1 case of grade III ependymoma. Gross tumor removal (GTR) was achieved in two patients (40%) of patients. One patient was treated with radiotherapy for recurrence and two patients received chemotherapy. There were no cases of recurrence among patients treated with GTR, but in all patients treated with STR. Eighty percent of patients either improved or stayed stable neurologically. During follow-up (mean 73 months), 2 patients died of disease. Conclusion: GTR and tumor grade remain the key prognostic factor of long-term tumor-free survival. Many questions prevail regarding outcomes, correct use of adjuvant therapy, and prognostic factors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NU21-07-00419" target="_blank" >NU21-07-00419: Molekulárně genetická charakterizace dětských mozkových nádorů asociovaných se syndromy predispozice k nádorovým onemocněním</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Child&apos;s Nervous System

ISSN

0256-7040

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1183-1192

Kód UT WoS článku

000904938900001

EID výsledku v databázi Scopus

2-s2.0-85144901217