Comparable outcomes in single versus multiple septal branches alcohol ablation for obstructive hypertrophic cardiomyopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10495913" target="_blank" >RIV/00064203:_____/25:10495913 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/25:10495913 RIV/00216208:11310/25:10495913

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8TCQuwpE71" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8TCQuwpE71</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2025.133145" target="_blank" >10.1016/j.ijcard.2025.133145</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparable outcomes in single versus multiple septal branches alcohol ablation for obstructive hypertrophic cardiomyopathy

Popis výsledku v původním jazyce

BACKGROUND: The optimal number of septal branches to target during initial alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) remains a subject of debate. It is unclear whether to proceed with ASA of additional septal branches if a satisfactory hemodynamic effect has not been achieved following ablation of the first branch. METHODS: Using propensity score matching analysis, we compared patients who achieved satisfactory outcomes after ASA of a single septal branch with those in whom additional branches were ablated. RESULTS: A total of 457 patients were included in the study, with a median follow-up of 5.61 years (interquartile range 2.08-10.91 years). Propensity score matching identified 92 pairs (184 patients), divided into the single-ablated-branch and more-ablated-branches groups. No significant differences were found in the incidence of major cardiovascular adverse events within the first 30 days between the two groups. Similarly, there were no differences in long-term outcomes between the matched single-ablated-branch and multiple-ablated-branches groups regarding all-cause mortality (3.77 vs.2.90 deaths per 100 patient-years, log-rank p = 0.649), re-intervention rates (12 % vs. 8 %; log-rank p = 0.345), left ventricular outflow gradient (14 +- 13 mmHg vs. 16 +- 15 mmHg; p = 0.209), or NYHA functional class (1.7 +- 0.6 vs. 1.6 +- 0.7; p = 0.629). CONCLUSIONS: In both short- and long-term follow-ups, ASA targeting single or multiple septal branches showed comparable efficacy and safety in patients with hypertrophic obstructive cardiomyopathy.

Název v anglickém jazyce

Comparable outcomes in single versus multiple septal branches alcohol ablation for obstructive hypertrophic cardiomyopathy

Popis výsledku anglicky

BACKGROUND: The optimal number of septal branches to target during initial alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) remains a subject of debate. It is unclear whether to proceed with ASA of additional septal branches if a satisfactory hemodynamic effect has not been achieved following ablation of the first branch. METHODS: Using propensity score matching analysis, we compared patients who achieved satisfactory outcomes after ASA of a single septal branch with those in whom additional branches were ablated. RESULTS: A total of 457 patients were included in the study, with a median follow-up of 5.61 years (interquartile range 2.08-10.91 years). Propensity score matching identified 92 pairs (184 patients), divided into the single-ablated-branch and more-ablated-branches groups. No significant differences were found in the incidence of major cardiovascular adverse events within the first 30 days between the two groups. Similarly, there were no differences in long-term outcomes between the matched single-ablated-branch and multiple-ablated-branches groups regarding all-cause mortality (3.77 vs.2.90 deaths per 100 patient-years, log-rank p = 0.649), re-intervention rates (12 % vs. 8 %; log-rank p = 0.345), left ventricular outflow gradient (14 +- 13 mmHg vs. 16 +- 15 mmHg; p = 0.209), or NYHA functional class (1.7 +- 0.6 vs. 1.6 +- 0.7; p = 0.629). CONCLUSIONS: In both short- and long-term follow-ups, ASA targeting single or multiple septal branches showed comparable efficacy and safety in patients with hypertrophic obstructive cardiomyopathy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cardiology

ISSN

0167-5273

e-ISSN

1874-1754

Svazek periodika

429

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

133145

Kód UT WoS článku

001449123100001

EID výsledku v databázi Scopus

2-s2.0-86000626399