A comparative study between CT angiography and flow parameters in hemodynamic phantom of carotid stenosis evaluated by duplex sonography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F25%3A10498867" target="_blank" >RIV/00064203:_____/25:10498867 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10498867

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JZiC59sxg4" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JZiC59sxg4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s41205-025-00271-0" target="_blank" >10.1186/s41205-025-00271-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A comparative study between CT angiography and flow parameters in hemodynamic phantom of carotid stenosis evaluated by duplex sonography

Popis výsledku v původním jazyce

BACKGROUND: The use of 3D-printed hemodynamic phantom of a stenotic carotid artery has not been extensively investigated. Our study aims to address this gap by exploring the correlation between CTA and flow parameters in hemodynamic phantom. METHODS: Patients with carotid stenosis were included in a prospective study. A realistic phantoms of carotid artery stenoses were 3D-printed based on CT angiography. Stenosis severity and hemodynamic flow parameters in the phantom evaluated using duplex sonography were correlated with CTA. The primary outcome was to compare the evaluation of the percentage of stenosis based on the measurement of diameter reduction and area reduction of the carotid artery among CTA, a 3D model constructed from CTA data, and ultrasound measurement of stenosis percentage within the 3D printed phantom. The secondary outcome was to determine whether the percentage of stenosis measured by ultrasound in B-mode or ultrasound-measured flow velocities (PSV, EDV) better correlates with the stenosis percentage derived from CTA and the phantom. RESULTS: The study included 95 subjects (average age 71 years, 75% male) with carotid stenosis, 39% were symptomatic. Significant correlations were found between ultrasound B-Mode findings on the phantom and CTA, with the strongest correlations for area reduction (Spearman r = 0.615, p &lt; 0.0001) and diameter reduction (Spearman r = 0.465, p &lt; 0.0001). The most robust correlation between PSV and EDV in stenosis and the percentage of stenosis was identified between PSV in stenosis and the percentage of stenosis by diameter reduction, as evaluated through ultrasound. The Spearman correlation coefficient revealed a relatively strong correlation, with a value of r = 0.444 (p &lt; 0.0001), and the Kendall Tau correlation coefficient also demonstrated significance, with a value of r = 0.302 (p &lt; 0.0001). CONCLUSIONS: A significant correlation between CTA and duplex sonography measurements on the carotid phantom was demostrated, suggesting the potential utilization of the phantom in testing hemodynamic parameters of carotid stenosis.

Název v anglickém jazyce

A comparative study between CT angiography and flow parameters in hemodynamic phantom of carotid stenosis evaluated by duplex sonography

Popis výsledku anglicky

BACKGROUND: The use of 3D-printed hemodynamic phantom of a stenotic carotid artery has not been extensively investigated. Our study aims to address this gap by exploring the correlation between CTA and flow parameters in hemodynamic phantom. METHODS: Patients with carotid stenosis were included in a prospective study. A realistic phantoms of carotid artery stenoses were 3D-printed based on CT angiography. Stenosis severity and hemodynamic flow parameters in the phantom evaluated using duplex sonography were correlated with CTA. The primary outcome was to compare the evaluation of the percentage of stenosis based on the measurement of diameter reduction and area reduction of the carotid artery among CTA, a 3D model constructed from CTA data, and ultrasound measurement of stenosis percentage within the 3D printed phantom. The secondary outcome was to determine whether the percentage of stenosis measured by ultrasound in B-mode or ultrasound-measured flow velocities (PSV, EDV) better correlates with the stenosis percentage derived from CTA and the phantom. RESULTS: The study included 95 subjects (average age 71 years, 75% male) with carotid stenosis, 39% were symptomatic. Significant correlations were found between ultrasound B-Mode findings on the phantom and CTA, with the strongest correlations for area reduction (Spearman r = 0.615, p &lt; 0.0001) and diameter reduction (Spearman r = 0.465, p &lt; 0.0001). The most robust correlation between PSV and EDV in stenosis and the percentage of stenosis was identified between PSV in stenosis and the percentage of stenosis by diameter reduction, as evaluated through ultrasound. The Spearman correlation coefficient revealed a relatively strong correlation, with a value of r = 0.444 (p &lt; 0.0001), and the Kendall Tau correlation coefficient also demonstrated significance, with a value of r = 0.302 (p &lt; 0.0001). CONCLUSIONS: A significant correlation between CTA and duplex sonography measurements on the carotid phantom was demostrated, suggesting the potential utilization of the phantom in testing hemodynamic parameters of carotid stenosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

3D printing in medicine

ISSN

—

e-ISSN

2365-6271

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

29

Kód UT WoS článku

001510495600001

EID výsledku v databázi Scopus

2-s2.0-105008227673