The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F19%3AW0002028" target="_blank" >RIV/00064211:_____/19:W0002028 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61388971:_____/19:00503686 RIV/67985904:_____/19:00503686 RIV/60162694:G44__/19:00536529 RIV/60460709:41210/19:78673
Výsledek na webu
<a href="https://dx.doi.org/10.1016/j.dci.2018.10.001" target="_blank" >https://dx.doi.org/10.1016/j.dci.2018.10.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2018.10.001" target="_blank" >10.1016/j.dci.2018.10.001</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine
Popis výsledku v původním jazyce
Using a porcine model, we describe Melanoma-Associated CD4(+)CD8(hi) T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4(+)CD8(hi) phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4(+)CD8(hi) TIL have a similar expression of selected markers indicating that they rep(re)sent effector/memory alpha beta T-cell subset. Moreover, although TIL also contain CD4(-)CD8(hi) T-cells, only CD4(+)CD8(hi) TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different melanoma loci among the same pig have similar composition of CD4/CD8 subsets, indicating that the composition of the MATL and TIL compartment is identical. Analysis of sorted cells from regressing pigs revealed a unique MATL subpopulation with mono-specific T-cell receptor that was further analyzed by sequencing. These results indicate that pigs regressing melanomas possess a characteristic population of recirculating T-cells playing a role in tumor control and regression.
Název v anglickém jazyce
The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine
Popis výsledku anglicky
Using a porcine model, we describe Melanoma-Associated CD4(+)CD8(hi) T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4(+)CD8(hi) phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4(+)CD8(hi) TIL have a similar expression of selected markers indicating that they rep(re)sent effector/memory alpha beta T-cell subset. Moreover, although TIL also contain CD4(-)CD8(hi) T-cells, only CD4(+)CD8(hi) TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different melanoma loci among the same pig have similar composition of CD4/CD8 subsets, indicating that the composition of the MATL and TIL compartment is identical. Analysis of sorted cells from regressing pigs revealed a unique MATL subpopulation with mono-specific T-cell receptor that was further analyzed by sequencing. These results indicate that pigs regressing melanomas possess a characteristic population of recirculating T-cells playing a role in tumor control and regression.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN
0145-305X
e-ISSN
1879-0089
Svazek periodika
92
Číslo periodika v rámci svazku
MAR
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
60-68
Kód UT WoS článku
000458596200007
EID výsledku v databázi Scopus
2-s2.0-85056618764