HIV infection and adverse perinatal outcomes - a meta-analysis of premature births, low birth weights, and small for gestational age newborns

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F25%3AW0000054" target="_blank" >RIV/00064211:_____/25:W0000054 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10503824 RIV/00216208:11510/25:10503824

Výsledek na webu

<a href="https://dx.doi.org/10.48095/cccg2025269" target="_blank" >https://dx.doi.org/10.48095/cccg2025269</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccg2025269" target="_blank" >10.48095/cccg2025269</a>

Jazyk výsledku

angličtina

Název v původním jazyce

HIV infection and adverse perinatal outcomes - a meta-analysis of premature births, low birth weights, and small for gestational age newborns

Popis výsledku v původním jazyce

HIV remains asignificantglobal public health challenge, affecting millions of individuals with a disproportionate burden in sub-Saharan Africa. Despite advancements in antiretroviral therapy (ART) and global efforts to control transmission, the impact of HIV on pregnancy outcomes remains a topic of concern. Aim: This study aims to evaluate the association between maternal HIV infection and adverse pregnancy outcomes, specifically preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) infants through a comprehensive meta-analysis. Materials and methods: A systematic search of English-language databases, including Medline, Web of Science, Ovid, Scopus, and Google Scholar, was conducted to identify relevant studies published between 2014 and 2024. Eligible studies included retrospective and prospective cohort studies with well-defined control groups of HIV-negative mothers. Studies that lacked appropriate control groups, included multiple pregnancies, or did not report adjusted statistical outcomes were excluded. A total of eight studies met the inclusion criteria for PTB analysis, five studies for LBW analysis, and five studies were selected for SGA analysis. Results: Meta-analysis using a random-effects model demonstrated a statistically significant association between maternal HIV infection and PTB (OR = 1.55; 95% CI 1.38-1.74; p < 0.001), LBW (OR = 1.57; 95% CI 1.24-1.98; p < 0.001), and an increased risk of SGA (OR = 1.24; 95% CI 1.10-1.40; p < 0.001). Heterogeneity was moderate for PTB (I2 = 38.2%) and LBW (I2 = 55.9%) while it was low for SGA (I2 = 7.6%), indicating consistency across studies. Egger's test showed minimal publication bias. Discussion: These findings highlight the adverse effects of HIV on pregnancy outcomes, emphasizing the need for continued monitoring and optimization of ART regimens to mitigate risks. Further research is warranted to explore the influence of different ART combinations and immune system dynamics on fetal development.

Název v anglickém jazyce

HIV infection and adverse perinatal outcomes - a meta-analysis of premature births, low birth weights, and small for gestational age newborns

Popis výsledku anglicky

HIV remains asignificantglobal public health challenge, affecting millions of individuals with a disproportionate burden in sub-Saharan Africa. Despite advancements in antiretroviral therapy (ART) and global efforts to control transmission, the impact of HIV on pregnancy outcomes remains a topic of concern. Aim: This study aims to evaluate the association between maternal HIV infection and adverse pregnancy outcomes, specifically preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) infants through a comprehensive meta-analysis. Materials and methods: A systematic search of English-language databases, including Medline, Web of Science, Ovid, Scopus, and Google Scholar, was conducted to identify relevant studies published between 2014 and 2024. Eligible studies included retrospective and prospective cohort studies with well-defined control groups of HIV-negative mothers. Studies that lacked appropriate control groups, included multiple pregnancies, or did not report adjusted statistical outcomes were excluded. A total of eight studies met the inclusion criteria for PTB analysis, five studies for LBW analysis, and five studies were selected for SGA analysis. Results: Meta-analysis using a random-effects model demonstrated a statistically significant association between maternal HIV infection and PTB (OR = 1.55; 95% CI 1.38-1.74; p < 0.001), LBW (OR = 1.57; 95% CI 1.24-1.98; p < 0.001), and an increased risk of SGA (OR = 1.24; 95% CI 1.10-1.40; p < 0.001). Heterogeneity was moderate for PTB (I2 = 38.2%) and LBW (I2 = 55.9%) while it was low for SGA (I2 = 7.6%), indicating consistency across studies. Egger's test showed minimal publication bias. Discussion: These findings highlight the adverse effects of HIV on pregnancy outcomes, emphasizing the need for continued monitoring and optimization of ART regimens to mitigate risks. Further research is warranted to explore the influence of different ART combinations and immune system dynamics on fetal development.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CESKA GYNEKOLOGIE-CZECH GYNAECOLOGY

ISSN

1210-7832

e-ISSN

1805-4455

Svazek periodika

90

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

269-277

Kód UT WoS článku

001609667800001

EID výsledku v databázi Scopus

—