An anaplastic cardiac large cell lymphoma: a case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin ´s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F17%3AN0000136" target="_blank" >RIV/00098892:_____/17:N0000136 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00099922 RIV/00843989:_____/17:E0106875

Výsledek na webu

<a href="https://nobleresearch.org/Doi/10.14312/2052-4994.2017-13" target="_blank" >https://nobleresearch.org/Doi/10.14312/2052-4994.2017-13</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14312/2052-4994.2017-13" target="_blank" >10.14312/2052-4994.2017-13</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An anaplastic cardiac large cell lymphoma: a case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin ´s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Popis výsledku v původním jazyce

We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the same – approximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.

Název v anglickém jazyce

An anaplastic cardiac large cell lymphoma: a case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin ´s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Popis výsledku anglicky

We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the same – approximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30205 - Hematology

Projekt

<a href="/cs/project/NV16-31092A" target="_blank" >NV16-31092A: Péče o nemocné staršího věku (?65 let) s Non-Hodgkinovými lymfomy – analýza faktorů ovlivňujících volbu léčby a osud nemocných</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF CANCER RESEARCH AND THERAPY

ISSN

2052-4994

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

66-71

Kód UT WoS článku

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EID výsledku v databázi Scopus

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