Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000081" target="_blank" >RIV/00098892:_____/18:N0000081 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/18:73589957

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study

Popis výsledku v původním jazyce

Objectives. Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). Methods. Thirty-two patients with ON due to MS within 3months of onset of symptoms were enrolled [22 females, 10 males, age 349years, median 32.5years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint((R)), Minneapolis, MN, USA). Results. Arterio-venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) 34.2 plus minus 4.7 versus 31.3 plus minus 4.6, p=0.044 (mean plus minus standard deviation). No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p<0.0001 for both comparisons). No correlation between oxygen saturation values and VEP was observed in patients with MS. Conclusion. The AVD in oxygen saturation is altered in patients with acute ON. In the early stage of ON, AVD could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in MS patients in suspicion of ON. This result would be promising for future investigation in this field.

Název v anglickém jazyce

Changes in oxygen saturation and the retinal nerve fibre layer in patients with optic neuritis - a pilot study

Popis výsledku anglicky

Objectives. Assessment of retinal oxygen saturation, thickness of a retinal nerve fibre layer (RNFL) and functional changes in the optic nerve during optic neuritis (ON) in patients with multiple sclerosis (MS). Methods. Thirty-two patients with ON due to MS within 3months of onset of symptoms were enrolled [22 females, 10 males, age 349years, median 32.5years, 22 patients with the clinically isolated syndrome (CIS), 10 patients with relapsing-remitting from of MS (RRMS)]. All patients were examined using optical coherence tomography (OCT model 4000, Carl Zeiss Meditec, Dublin, CA, USA), automatic optical oximetry (Oxymap ehf, Reykjavik, Iceland) and using visual evoked potentials (VEP) (Metronic Keypoint((R)), Minneapolis, MN, USA). Results. Arterio-venous difference (AVD) was increased in patients ON affected eye compared to patients' unaffected eye (PUE) 34.2 plus minus 4.7 versus 31.3 plus minus 4.6, p=0.044 (mean plus minus standard deviation). No statistically significant difference was found in vessel oxygen saturation as well as in RNFL thickness in ON affected eyes when compared to unaffected MS eyes and healthy individuals. Significantly lower optic nerve conduction velocity was found in the affected eye when compared to unaffected MS eye and healthy (p<0.0001 for both comparisons). No correlation between oxygen saturation values and VEP was observed in patients with MS. Conclusion. The AVD in oxygen saturation is altered in patients with acute ON. In the early stage of ON, AVD could reflect inflammatory and metabolic changes in the affected eye. Therefore, oximetry could be used as another diagnostic method in MS patients in suspicion of ON. This result would be promising for future investigation in this field.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Ophthalmologica

ISSN

1755-375X

e-ISSN

—

Svazek periodika

96

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

6

Strana od-do

309-314

Kód UT WoS článku

000430912700007

EID výsledku v databázi Scopus

2-s2.0-85032811888