Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157730" target="_blank" >RIV/00098892:_____/22:10157730 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/22:73613129

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11914-022-00720-3" target="_blank" >https://link.springer.com/article/10.1007/s11914-022-00720-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11914-022-00720-3" target="_blank" >10.1007/s11914-022-00720-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis

Popis výsledku v původním jazyce

Purpose of Review: Joint replacement has revolutionized the treatment of end-stage arthritis. We highlight the key role of macrophages in the innate immune system in helping to ensure that the prosthesis-host interface remains biologically robust. Recent Findings: Osteoimmunology is of great interest to researchers investigating the fundamental biological and material aspects of joint replacement. Constant communication between cells of the monocyte/macrophage/osteoclast lineage and the mesenchymal stem cell-osteoblast lineage determines whether a durable prosthesis-implant interface is obtained, or whether implant loosening occurs. Tissue and circulating monocytes/macrophages provide local surveillance of stimuli such as the presence of byproducts of wear and can quickly polarize to pro- and anti-inflammatory phenotypes to re-establish tissue homeostasis. When these mechanisms fail, periprosthetic osteolysis results in progressive bone loss and painful failure of mechanical fixation. Summary: Immune modulation of the periprosthetic microenvironment is a potential intervention to facilitate long-term durability of prosthetic interfaces.

Název v anglickém jazyce

Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis

Popis výsledku anglicky

Purpose of Review: Joint replacement has revolutionized the treatment of end-stage arthritis. We highlight the key role of macrophages in the innate immune system in helping to ensure that the prosthesis-host interface remains biologically robust. Recent Findings: Osteoimmunology is of great interest to researchers investigating the fundamental biological and material aspects of joint replacement. Constant communication between cells of the monocyte/macrophage/osteoclast lineage and the mesenchymal stem cell-osteoblast lineage determines whether a durable prosthesis-implant interface is obtained, or whether implant loosening occurs. Tissue and circulating monocytes/macrophages provide local surveillance of stimuli such as the presence of byproducts of wear and can quickly polarize to pro- and anti-inflammatory phenotypes to re-establish tissue homeostasis. When these mechanisms fail, periprosthetic osteolysis results in progressive bone loss and painful failure of mechanical fixation. Summary: Immune modulation of the periprosthetic microenvironment is a potential intervention to facilitate long-term durability of prosthetic interfaces.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30211 - Orthopaedics

Projekt

<a href="/cs/project/NU21-06-00370" target="_blank" >NU21-06-00370: Odlišení low-grade infekce TEP kyčle a kolena od aseptických komplikací s využitím imunocytologické analýzy a strojového učení</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Osteoporosis Reports

ISSN

1544-1873

e-ISSN

1544-2241

Svazek periodika

20

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

43-52

Kód UT WoS článku

000752742600001

EID výsledku v databázi Scopus

2-s2.0-85124391747