Macrophages-Key cells in the response to wear debris from joint replacements.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33148509" target="_blank" >RIV/61989592:15110/13:33148509 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jbm.a.34599" target="_blank" >http://dx.doi.org/10.1002/jbm.a.34599</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.34599" target="_blank" >10.1002/jbm.a.34599</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Macrophages-Key cells in the response to wear debris from joint replacements.

Popis výsledku v původním jazyce

The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone destruction, and eventually, implant loosening, and revision surgery. The latter may be indicated in up to 15% patients in the decade following the arthroplasty using conventional polyethylene. Macrophages play multiple roles in both inflammation and in maintaining tissue homeostasis. Assentinels of the innate immune system, they are central to the initiation of this inflammatory cascade, characterized by the release of proinflammatory and pro-osteoclastic factors. Similar to the response to pathogens, wear particles elicit a macrophage response, based on the unique properties of the cells belonging to this lineage, including sensing, chemotaxis, phagocytosis, and adaptive stimulation. The biological processes involved are complex, redundant, both local and systemic, a

Název v anglickém jazyce

Macrophages-Key cells in the response to wear debris from joint replacements.

Popis výsledku anglicky

The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone destruction, and eventually, implant loosening, and revision surgery. The latter may be indicated in up to 15% patients in the decade following the arthroplasty using conventional polyethylene. Macrophages play multiple roles in both inflammation and in maintaining tissue homeostasis. Assentinels of the innate immune system, they are central to the initiation of this inflammatory cascade, characterized by the release of proinflammatory and pro-osteoclastic factors. Similar to the response to pathogens, wear particles elicit a macrophage response, based on the unique properties of the cells belonging to this lineage, including sensing, chemotaxis, phagocytosis, and adaptive stimulation. The biological processes involved are complex, redundant, both local and systemic, a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FI - Traumatologie a ortopedie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11049" target="_blank" >NT11049: Exprese genů klíčových molekul zánětu v periprotetických tkáních: první krok k časově podmíněné analýze periprotetické osteolýzy.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biomedical Materials Research. Part A

ISSN

1549-3296

e-ISSN

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Svazek periodika

101

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

3033-3045

Kód UT WoS článku

000323648300028

EID výsledku v databázi Scopus

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