Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33143644" target="_blank" >RIV/61989592:15110/13:33143644 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/13:#0000488

Výsledek na webu

<a href="http://dx.doi.org/10.1177/1753425912451779" target="_blank" >http://dx.doi.org/10.1177/1753425912451779</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1753425912451779" target="_blank" >10.1177/1753425912451779</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

Popis výsledku v původním jazyce

Numerous studies provide detailed insight into the triggering and amplification mechanisms of the inflammatory response associated with prosthetic wear particles, promoting final dominance of bone resorption over bone formation in multiple bone multicellular units around an implant. In fact, inflammation is a highly regulated process tightly linked to simultaneous stimulation of tissue protective and regenerative mechanisms in order to prevent collateral damage of periprosthetic tissues. A variety of cytokines, chemokines, hormones and specific cell populations, including macrophages, dendritic and stem cells, attempt to balance tissue architecture and minimize inflammation. Based on this fact, we postulate that the local tissue homeostatic mechanismsmore effectively regulate the pro-inflammatory/pro-osteolytic cells/pathways in patients with none/mild periprosthetic osteolysis (PPOL) than in patients with severe PPOL. In this line of thinking, 'particle disease theory' can be underst

Název v anglickém jazyce

Particle disease: Biologic mechanisms of periprosthetic osteolysis in total hip arthroplasty

Popis výsledku anglicky

Numerous studies provide detailed insight into the triggering and amplification mechanisms of the inflammatory response associated with prosthetic wear particles, promoting final dominance of bone resorption over bone formation in multiple bone multicellular units around an implant. In fact, inflammation is a highly regulated process tightly linked to simultaneous stimulation of tissue protective and regenerative mechanisms in order to prevent collateral damage of periprosthetic tissues. A variety of cytokines, chemokines, hormones and specific cell populations, including macrophages, dendritic and stem cells, attempt to balance tissue architecture and minimize inflammation. Based on this fact, we postulate that the local tissue homeostatic mechanismsmore effectively regulate the pro-inflammatory/pro-osteolytic cells/pathways in patients with none/mild periprosthetic osteolysis (PPOL) than in patients with severe PPOL. In this line of thinking, 'particle disease theory' can be underst

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FI - Traumatologie a ortopedie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11049" target="_blank" >NT11049: Exprese genů klíčových molekul zánětu v periprotetických tkáních: první krok k časově podmíněné analýze periprotetické osteolýzy.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Innate Immunity

ISSN

1662-811X

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

213-224

Kód UT WoS článku

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EID výsledku v databázi Scopus

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