Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10158889" target="_blank" >RIV/00098892:_____/25:10158889 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1499387224001589?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1499387224001589?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.hbpd.2024.11.003" target="_blank" >10.1016/j.hbpd.2024.11.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study

Popis výsledku v původním jazyce

Biliary strictures are caused by both benign and malignant pathologies. Although up to 30% of biliary strictures are identified as benign, the vast majority are malignant with two major malignancies, namely pancreatic adenocarcinoma and cholangiocarcinoma (CC). Accurate diagnosis and precise localization play a vital role in the prognosis and management of the disease. In this study we primarily focused on the diagnosis of CC. The highest incidence of CC is in northeastern Thailand, where the incidence is found to be 100/100 000 in males and 50/100 000 in females. In Western countries, it is approximately (0.5–2.0)/100 000 individuals. CC is most often diagnosed between the ages of 70 and 80 years. The prognosis of biliary malignancies is dismal with overall five-year survival as low as 10%. We developed a new method that can provide real-time Raman measurements of biliary stricture and physiological bile duct tissue during an ERCP procedure. The method is based on the utilization of a portable Raman system equipped with a fiber-optic probe. Then the resulting raw data are subjected to spectral processing and statistical evaluation, including a cluster analysis.

Název v anglickém jazyce

Raman spectroscopy in the diagnosis of malignant biliary stricture: A feasibility study

Popis výsledku anglicky

Biliary strictures are caused by both benign and malignant pathologies. Although up to 30% of biliary strictures are identified as benign, the vast majority are malignant with two major malignancies, namely pancreatic adenocarcinoma and cholangiocarcinoma (CC). Accurate diagnosis and precise localization play a vital role in the prognosis and management of the disease. In this study we primarily focused on the diagnosis of CC. The highest incidence of CC is in northeastern Thailand, where the incidence is found to be 100/100 000 in males and 50/100 000 in females. In Western countries, it is approximately (0.5–2.0)/100 000 individuals. CC is most often diagnosed between the ages of 70 and 80 years. The prognosis of biliary malignancies is dismal with overall five-year survival as low as 10%. We developed a new method that can provide real-time Raman measurements of biliary stricture and physiological bile duct tissue during an ERCP procedure. The method is based on the utilization of a portable Raman system equipped with a fiber-optic probe. Then the resulting raw data are subjected to spectral processing and statistical evaluation, including a cluster analysis.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hepatobiliary &amp; Pancreatic Diseases International

ISSN

1499-3872

e-ISSN

2352-9377

Svazek periodika

24

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

211-216

Kód UT WoS článku

001661924600001

EID výsledku v databázi Scopus

2-s2.0-85211481965