Prognostic impact of immune phenotype in oral squamous cell carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F25%3A10159333" target="_blank" >RIV/00098892:_____/25:10159333 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00141926 RIV/61989592:15110/25:73635898 RIV/00159816:_____/25:00082345

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1368837525003975?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1368837525003975?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.oraloncology.2025.107568" target="_blank" >10.1016/j.oraloncology.2025.107568</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic impact of immune phenotype in oral squamous cell carcinoma

Popis výsledku v původním jazyce

Background: In oral squamous cell carcinoma (OSCC), the current staging system fails to reliably identify high-risk patients, and potential biomarkers improving the prognostic, and predictive stratification of OSCC are sought. Due to the importance of tumor immune microenvironment in the development and progression of cancer, here we investigated the prognostic impact of immune phenotypes in OSCC. Methods: The study included 119 OSCC patients treated by curative surgery. Based on the extent and spatial distribution of TILs in hematoxylin and eosin-staining, the tumors were classified as immune-excluded, immune-inflamed, and immune-desert. The prognostic significance and clinicopathological correlations of immune phenotypes were investigated, immunohistochemically detected PD-L1 expression levels were correlated with immune phenotypes. Results: Immune-desert and immune-inflamed phenotypes significantly correlated with lymph node metastasis, higher stage, grade, and perineural invasion. A higher incidence of local recurrence was demonstrated in patients with immune-inflamed phenotype. PD-L1 expression levels correlated with immune phenotypes, with the highest expression levels in inflamed tumors. In Kaplan-Meier analysis, inferior survival rates were demonstrated in immune-desert and immune-inflamed OSCC (p &lt; 0.0001). Cox regression showed an independent negative prognostic impact of both immune-inflamed and immune-desert phenotypes on disease-free (HR 5.327 and 4.256, respectively), disease-specific (HR 12.09 and 4.337), and overall survival (HR 4.502 and 4.300). Conclusions: Our findings support that the histological evaluation of tumor immune phenotype might provide significant information on OSCC hazard discrimination, prognostication, and treatment decisions. The study identified immune-desert and immune-inflamed OSCC phenotypes associated with worse prognosis reflecting the lack of pre-existing anti-tumor immunity or immunosuppressive tumor immune microenvironment.

Název v anglickém jazyce

Prognostic impact of immune phenotype in oral squamous cell carcinoma

Popis výsledku anglicky

Background: In oral squamous cell carcinoma (OSCC), the current staging system fails to reliably identify high-risk patients, and potential biomarkers improving the prognostic, and predictive stratification of OSCC are sought. Due to the importance of tumor immune microenvironment in the development and progression of cancer, here we investigated the prognostic impact of immune phenotypes in OSCC. Methods: The study included 119 OSCC patients treated by curative surgery. Based on the extent and spatial distribution of TILs in hematoxylin and eosin-staining, the tumors were classified as immune-excluded, immune-inflamed, and immune-desert. The prognostic significance and clinicopathological correlations of immune phenotypes were investigated, immunohistochemically detected PD-L1 expression levels were correlated with immune phenotypes. Results: Immune-desert and immune-inflamed phenotypes significantly correlated with lymph node metastasis, higher stage, grade, and perineural invasion. A higher incidence of local recurrence was demonstrated in patients with immune-inflamed phenotype. PD-L1 expression levels correlated with immune phenotypes, with the highest expression levels in inflamed tumors. In Kaplan-Meier analysis, inferior survival rates were demonstrated in immune-desert and immune-inflamed OSCC (p &lt; 0.0001). Cox regression showed an independent negative prognostic impact of both immune-inflamed and immune-desert phenotypes on disease-free (HR 5.327 and 4.256, respectively), disease-specific (HR 12.09 and 4.337), and overall survival (HR 4.502 and 4.300). Conclusions: Our findings support that the histological evaluation of tumor immune phenotype might provide significant information on OSCC hazard discrimination, prognostication, and treatment decisions. The study identified immune-desert and immune-inflamed OSCC phenotypes associated with worse prognosis reflecting the lack of pre-existing anti-tumor immunity or immunosuppressive tumor immune microenvironment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oral Oncology

ISSN

1368-8375

e-ISSN

1879-0593

Svazek periodika

168

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

107568

Kód UT WoS článku

001542479700002

EID výsledku v databázi Scopus

2-s2.0-105011869537