Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061518" target="_blank" >RIV/00159816:_____/14:00061518 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/14:00080165

Výsledek na webu

<a href="http://dx.doi.org/10.1097/PRS.0000000000000570" target="_blank" >http://dx.doi.org/10.1097/PRS.0000000000000570</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/PRS.0000000000000570" target="_blank" >10.1097/PRS.0000000000000570</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model

Popis výsledku v původním jazyce

Background: There has been no review study published yet comparing the effects of the vasodilating drugs that are most often used in clinical practice empirically. The aim of the authors' study was to perform this comparison and to select the drugs thatare able to release vasospasm and the drugs that reduce vasospasm duration most effectively in an experimental model in vivo. Methods: Pedicled groin flaps were dissected in 300 male Wistar rats. Vasospasm was induced by tension applied on the pedicle inthe axial direction using a 15-g weight. The blood perfusion of the flap was monitored using a laser Doppler device. The duration of vasospasm was defined as the time from the release of tension until blood flow began to rise. These times were detectedusing automated computerized detection. The effects of 11 different drugs were studied in 14 groups. The drugs were applied locally; some of them were tested in different concentrations or applied parenterally. Results: Ten percent magnes

Název v anglickém jazyce

Vasospasm of the Flap Pedicle: The Effect of 11 of the Most Often Used Vasodilating Drugs. Comparative Study in a Rat Model

Popis výsledku anglicky

Background: There has been no review study published yet comparing the effects of the vasodilating drugs that are most often used in clinical practice empirically. The aim of the authors' study was to perform this comparison and to select the drugs thatare able to release vasospasm and the drugs that reduce vasospasm duration most effectively in an experimental model in vivo. Methods: Pedicled groin flaps were dissected in 300 male Wistar rats. Vasospasm was induced by tension applied on the pedicle inthe axial direction using a 15-g weight. The blood perfusion of the flap was monitored using a laser Doppler device. The duration of vasospasm was defined as the time from the release of tension until blood flow began to rise. These times were detectedusing automated computerized detection. The effects of 11 different drugs were studied in 14 groups. The drugs were applied locally; some of them were tested in different concentrations or applied parenterally. Results: Ten percent magnes

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NR8368" target="_blank" >NR8368: Spazmy cév mikrochirurgicky přenášených laloků a možnosti jejich ovlivnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plastic and Reconstructive Surgery

ISSN

0032-1052

e-ISSN

—

Svazek periodika

134

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

"574E"-"584E"

Kód UT WoS článku

000343105400009

EID výsledku v databázi Scopus

—