The Significance Of (CA)n Tandem Repeat in GABA(A) Beta-3 Subunit Gene in Tinnitus Manifestation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00062497" target="_blank" >RIV/00159816:_____/14:00062497 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/14:00080148

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Significance Of (CA)n Tandem Repeat in GABA(A) Beta-3 Subunit Gene in Tinnitus Manifestation

Popis výsledku v původním jazyce

Study aim: Study objective was to explore associations between manifestation of tinnitus, auditory evoked potentials and genetic background of gamma-aminobutyric acid type A (GABA(A) receptors) to support the disinhibited feedback hypothesis of tinnitusgeneration. Materials and methods: A population of 131 patients was assessed for severity of hearing loss, quantification of tinnitus, mid-latency responses (MLR) and brainstem auditory evoked potentials (BAEP), and (CA)n tandem repeat polymorphism in GABA(A) Beta-3 subunit gene to establish any correlation with manifestation of tinnitus. Results: It was observed that tinnitus score correlates with V/III amplitude ratio in BAEP (R = 0.22, p < 0.001) and with mean pure tone audiometry (PTA) threshold (R= 0.22, p = 0.017). Analysis of the MLR results showed a significant correlation between the PA wave amplitude and the tinnitus score (R = 0.31-0.37; p < 0.001). MLR result analysis showed no statistically significant correlation between

Název v anglickém jazyce

The Significance Of (CA)n Tandem Repeat in GABA(A) Beta-3 Subunit Gene in Tinnitus Manifestation

Popis výsledku anglicky

Study aim: Study objective was to explore associations between manifestation of tinnitus, auditory evoked potentials and genetic background of gamma-aminobutyric acid type A (GABA(A) receptors) to support the disinhibited feedback hypothesis of tinnitusgeneration. Materials and methods: A population of 131 patients was assessed for severity of hearing loss, quantification of tinnitus, mid-latency responses (MLR) and brainstem auditory evoked potentials (BAEP), and (CA)n tandem repeat polymorphism in GABA(A) Beta-3 subunit gene to establish any correlation with manifestation of tinnitus. Results: It was observed that tinnitus score correlates with V/III amplitude ratio in BAEP (R = 0.22, p < 0.001) and with mean pure tone audiometry (PTA) threshold (R= 0.22, p = 0.017). Analysis of the MLR results showed a significant correlation between the PA wave amplitude and the tinnitus score (R = 0.31-0.37; p < 0.001). MLR result analysis showed no statistically significant correlation between

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NS10101" target="_blank" >NS10101: Genetické aspekty ototoxicity indukované cisplatinou - prospektivní asociační studie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

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Svazek periodika

77

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

473-478

Kód UT WoS článku

000339709800010

EID výsledku v databázi Scopus

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