Polymorfismus NMDA receptoru, DRD2 receptoru, GABA-A receptoru a variabilita elektrofyziologických odpovdí BAEP a MLR ve vztahu k manifestaci tinnitu - pedbžná zpráva

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00018998" target="_blank" >RIV/00216224:14110/04:00018998 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation preliminary report.

Popis výsledku v původním jazyce

Prospective study of 50 patients demonstrate the associations between tinnitus manifestation (multiple data acquired by help of a tinnitus questionnaire) emotional lability, and Taq I polymorphism of the DRD-2, three single nucleotide polymorphism in GRIN2A subunit of the NMDA receptor and CA repeat in GABRB3 subunit of the GABA-A receptor and changes of amplitude in BAEP and MLR response waveforms which can signalize the desinhibition of the central auditory pathways. The statistically significant correlation between the tinnitus score and the V/III amplitude ratios at intensities 110 (p=0,002) and 100 dB peSPL (p=0,025) has been found. The amplitude of Pa wave of MLR response correlates significantly with tinnitus score as well (p=0.006-0.05), Thereis also a statistically significant dependency between the V/III ratio and the amplitude of Pa wave (p=0,046 at 110 dB). The genetic analysis shows the difference of the tinnitus score according to genotypes of polymorphism GRIN2a MSP (le

Název v anglickém jazyce

Polymorphisms of NMDA receptor, DRD2 receptor, GABA-A receptor and electrophysiologic variations found in BAEP and MLR in relation to tinnitus manifestation preliminary report.

Popis výsledku anglicky

Prospective study of 50 patients demonstrate the associations between tinnitus manifestation (multiple data acquired by help of a tinnitus questionnaire) emotional lability, and Taq I polymorphism of the DRD-2, three single nucleotide polymorphism in GRIN2A subunit of the NMDA receptor and CA repeat in GABRB3 subunit of the GABA-A receptor and changes of amplitude in BAEP and MLR response waveforms which can signalize the desinhibition of the central auditory pathways. The statistically significant correlation between the tinnitus score and the V/III amplitude ratios at intensities 110 (p=0,002) and 100 dB peSPL (p=0,025) has been found. The amplitude of Pa wave of MLR response correlates significantly with tinnitus score as well (p=0.006-0.05), Thereis also a statistically significant dependency between the V/III ratio and the amplitude of Pa wave (p=0,046 at 110 dB). The genetic analysis shows the difference of the tinnitus score according to genotypes of polymorphism GRIN2a MSP (le

Druh

D - Stať ve sborníku

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

<a href="/cs/project/NM7472" target="_blank" >NM7472: Elektrofyziologické a genetické aspekty tinnitu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

5th European Congress of Oto-Rhino-Laryngology, Head and Neck Surgery, Rhodos, Hellas, Sept. 11-16, 2004

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

2

Strana od-do

192-193

Název nakladatele

C&C International

Místo vydání

Rhodos

Místo konání akce

Rhodos

Datum konání akce

11. 9. 2004

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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