Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063743" target="_blank" >RIV/00159816:_____/15:00063743 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/joic.12251" target="_blank" >http://dx.doi.org/10.1111/joic.12251</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/joic.12251" target="_blank" >10.1111/joic.12251</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI

Popis výsledku v původním jazyce

Background: Bleeding after percutaneous coronary interventions (PCI) is an important complication with impact on prognosis. Aim: To evaluate the predictive value of enhanced platelet responsiveness to dual antiplatelet therapy with aspirin and clopidogrel, for bleeding, after elective PCI. Methods and Results: We performed multiple electrode aggregometry (MAE) platelet functional tests induced by arachidonic acid (ASPI) and adenosine-diphosphate (ADP) before PCI, and 24 hours after PCI, in 481 electivePCI patients who were followed-up for an average of 15.34 +/- 7.19 months. Primary end point was the occurrence of any bleeding, while ischemic major adverse cardiovascular event (MACE) was a secondary endpoint. The incidence of total, BARC {= 2, and BARC }= 3 bleeding, according to BARC classification, was 19, 18, and 1%, respectively. Groups with any, and BARC {= 2 bleeding, had a lower average value of MAE ADP test after 24 hours, compared to the group without bleeding: 45.30 +/- 18.6

Název v anglickém jazyce

Low On-Treatment Platelet Reactivity Predicts Long-Term Risk of Bleeding After Elective PCI

Popis výsledku anglicky

Background: Bleeding after percutaneous coronary interventions (PCI) is an important complication with impact on prognosis. Aim: To evaluate the predictive value of enhanced platelet responsiveness to dual antiplatelet therapy with aspirin and clopidogrel, for bleeding, after elective PCI. Methods and Results: We performed multiple electrode aggregometry (MAE) platelet functional tests induced by arachidonic acid (ASPI) and adenosine-diphosphate (ADP) before PCI, and 24 hours after PCI, in 481 electivePCI patients who were followed-up for an average of 15.34 +/- 7.19 months. Primary end point was the occurrence of any bleeding, while ischemic major adverse cardiovascular event (MACE) was a secondary endpoint. The incidence of total, BARC {= 2, and BARC }= 3 bleeding, according to BARC classification, was 19, 18, and 1%, respectively. Groups with any, and BARC {= 2 bleeding, had a lower average value of MAE ADP test after 24 hours, compared to the group without bleeding: 45.30 +/- 18.6

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Interventional Cardiology

ISSN

0896-4327

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

531-543

Kód UT WoS článku

000366398100004

EID výsledku v databázi Scopus

—