Liposomal delivery systems for anti-cancer analogues of vitamin E

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00065555" target="_blank" >RIV/00159816:_____/15:00065555 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/15:00444631

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jconrel.2015.04.003" target="_blank" >http://dx.doi.org/10.1016/j.jconrel.2015.04.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jconrel.2015.04.003" target="_blank" >10.1016/j.jconrel.2015.04.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Liposomal delivery systems for anti-cancer analogues of vitamin E

Popis výsledku v původním jazyce

Pro-apoptotic analogues of vitamin E (VE) exert selective anti-cancer effect on various animal cancer models. Neither suitable formulation of a-tocopheryl succinate (alpha-TOS), representative semi-synthetic VE analogue ester, nor suitable formulations of the other VE analogues for clinical application have been reported yet. The major factor limiting the use of VE analogues is their low solubility in aqueous solvents. Due to the hydrophobic character of VE analogues, liposomes are predetermined as suitable delivery system. Liposomal formulation prevents undesirable side effects of the drug, enhances the drug biocompatibility, and improves the drug therapeutic index. Liposomal formulations of VE analogues especially of alpha-TOS and alpha-tocopheryl ether linked acetic acid (alpha-TEA) have been developed. The anti-cancer effect of these liposomal VE analogues has been successfully demonstrated in pre-clinical models in vivo. Present achievements in: (i) preparation of liposomal formulations of VE analogues, (ii) physico-chemical characterization of these developed systems and (iii) testing of their biological activity such as induction of apoptosis and evaluation of anti-cancer effect are discussed in this review.

Název v anglickém jazyce

Liposomal delivery systems for anti-cancer analogues of vitamin E

Popis výsledku anglicky

Pro-apoptotic analogues of vitamin E (VE) exert selective anti-cancer effect on various animal cancer models. Neither suitable formulation of a-tocopheryl succinate (alpha-TOS), representative semi-synthetic VE analogue ester, nor suitable formulations of the other VE analogues for clinical application have been reported yet. The major factor limiting the use of VE analogues is their low solubility in aqueous solvents. Due to the hydrophobic character of VE analogues, liposomes are predetermined as suitable delivery system. Liposomal formulation prevents undesirable side effects of the drug, enhances the drug biocompatibility, and improves the drug therapeutic index. Liposomal formulations of VE analogues especially of alpha-TOS and alpha-tocopheryl ether linked acetic acid (alpha-TEA) have been developed. The anti-cancer effect of these liposomal VE analogues has been successfully demonstrated in pre-clinical models in vivo. Present achievements in: (i) preparation of liposomal formulations of VE analogues, (ii) physico-chemical characterization of these developed systems and (iii) testing of their biological activity such as induction of apoptosis and evaluation of anti-cancer effect are discussed in this review.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Controlled Release

ISSN

0168-3659

e-ISSN

—

Svazek periodika

207

Číslo periodika v rámci svazku

2015

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

59-69

Kód UT WoS článku

000354060000006

EID výsledku v databázi Scopus

—