Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F11%3A00369496" target="_blank" >RIV/86652036:_____/11:00369496 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/mnfr.201100066" target="_blank" >http://dx.doi.org/10.1002/mnfr.201100066</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mnfr.201100066" target="_blank" >10.1002/mnfr.201100066</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

Popis výsledku v původním jazyce

Vitamin E (VE) analogues, epitomised by the prototypic alpha-tocopheryl succinate (alpha-TOS), are potent anti-cancer agents. alpha-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Q(P)) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R(2) value >0.8) with their toxicity to cancer cells. These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs.

Název v anglickém jazyce

Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells

Popis výsledku anglicky

Vitamin E (VE) analogues, epitomised by the prototypic alpha-tocopheryl succinate (alpha-TOS), are potent anti-cancer agents. alpha-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Q(P)) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R(2) value >0.8) with their toxicity to cancer cells. These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Nutrition & Food Research

ISSN

1613-4125

e-ISSN

—

Svazek periodika

55

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1543-1551

Kód UT WoS článku

000296547700012

EID výsledku v databázi Scopus

—