Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00065640" target="_blank" >RIV/00159816:_____/15:00065640 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/15:00090186

Výsledek na webu

<a href="https://www.degruyter.com/view/j/bjmg.2015.18.issue-2/bjmg-2015-0084/bjmg-2015-0084.xml" target="_blank" >https://www.degruyter.com/view/j/bjmg.2015.18.issue-2/bjmg-2015-0084/bjmg-2015-0084.xml</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/bjmg-2015-0084" target="_blank" >10.1515/bjmg-2015-0084</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus

Popis výsledku v původním jazyce

The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.

Název v anglickém jazyce

Association of the ACE rs4646994 and rs4341 Polymorphisms with the Progression of Carotid Atherosclerosis in Slovenian Patients with Type 2 Diabetes Mellitus

Popis výsledku anglicky

The current study was designed to reveal possible associations between the angiotensin-converting-enzyme (ACE) gene polymorphisms (rs4646994 and rs4341) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM) in a 4-year-long follow-up study. Five hundred and ninety-five T2DM subjects and 200 control subjects were enrolled. Genotyping of ACE polymorphisms was performed using KASPar assays, and ultrasound examinations were performed twice (at the enrollment and at follow-up). With regard to the progression of atherosclerosis in subjects with T2DM, statistically significant differences were demonstrated in the change of the sum of carotid plaques thickness for the rs4646994 polymorphism. We did not demonstrate an association between the tested polymorphisms (rs4646994 and rs4341) and either carotid intima media thickness (CIMT) or CIMT progression in a 3.8-year period. In our study, we demonstrated that subjects with T2DM with the DD genotype of the rs4646994 [ACE insertion/deletion (I/D)] polymorphism had faster progression of atherosclerosis in comparison to subjects with other genotypes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Balkan journal of medical genetics

ISSN

1311-0160

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

MK - Republika Severní Makedonie

Počet stran výsledku

6

Strana od-do

37-42

Kód UT WoS článku

000375181600005

EID výsledku v databázi Scopus

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