Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism (rs12762303) and arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene polymorphism (rs3802278) and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00113808" target="_blank" >RIV/00216224:14110/16:00113808 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/16:43874482

Výsledek na webu

<a href="http://www.ijcem.com/files/ijcem0014523.pdf" target="_blank" >http://www.ijcem.com/files/ijcem0014523.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism (rs12762303) and arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene polymorphism (rs3802278) and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

Popis výsledku v původním jazyce

Background: The study was designed to investigate the association between polymorphisms of the. arachidonate 5-lipoxygenase (ALOX5) gene (rs12762303) and the arachidonate 5-lipoxygenase-activating proteingene (rs3802278), and markers of carotid atherosclerosis, such as carotid intima media thickness, the number of affected segments of carotid arteries and the sum of plaque thickness in patients with T2DM. Patients and methods: 595 T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Genotyping of the ALOX5 gene (rs12762303) and the ALOX5AP gene (rs3802278) was performed using KASPar assays. Results: In our study, we demonstrated an association between the rs3802278 and CIMT, and between the rs12762303 and coronary calcium score in subjects with T2DM. In our study, we did not demonstrate any association between tested polymorphisms (rs12762303 and rs3802278) and the sum of plaque thickness, the number of involved segments, hsCRP, the presence of carotid plaques or the presence of unstable carotid plaques. Conclusions: To conclude, in our study we demonstrated an association between the rs3802278 and CIMT, and between the rs12762303 and coronary calcium score in subjects with T2DM.

Název v anglickém jazyce

Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism (rs12762303) and arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene polymorphism (rs3802278) and markers of carotid atherosclerosis in patients with type 2 diabetes mellitus

Popis výsledku anglicky

Background: The study was designed to investigate the association between polymorphisms of the. arachidonate 5-lipoxygenase (ALOX5) gene (rs12762303) and the arachidonate 5-lipoxygenase-activating proteingene (rs3802278), and markers of carotid atherosclerosis, such as carotid intima media thickness, the number of affected segments of carotid arteries and the sum of plaque thickness in patients with T2DM. Patients and methods: 595 T2DM subjects and 200 control subjects were enrolled. The carotid intima-media thickness (CIMT) and plaque characteristics (presence and structure) were assessed ultrasonographically. Biochemical analyses were performed using standard biochemical methods. Genotyping of the ALOX5 gene (rs12762303) and the ALOX5AP gene (rs3802278) was performed using KASPar assays. Results: In our study, we demonstrated an association between the rs3802278 and CIMT, and between the rs12762303 and coronary calcium score in subjects with T2DM. In our study, we did not demonstrate any association between tested polymorphisms (rs12762303 and rs3802278) and the sum of plaque thickness, the number of involved segments, hsCRP, the presence of carotid plaques or the presence of unstable carotid plaques. Conclusions: To conclude, in our study we demonstrated an association between the rs3802278 and CIMT, and between the rs12762303 and coronary calcium score in subjects with T2DM.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30230 - Other clinical medicine subjects

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Clinical and Experimental Medicine

ISSN

1940-5901

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

4509-4514

Kód UT WoS článku

000374655200490

EID výsledku v databázi Scopus

2-s2.0-84962278962