Correlations of the changes in bioptic findings with echocardiographic, clinical and laboratory parameters in patients with inflammatory cardiomyopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00062941" target="_blank" >RIV/00159816:_____/16:00062941 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00089216 RIV/00209775:_____/16:N0000012

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00380-014-0618-0" target="_blank" >http://dx.doi.org/10.1007/s00380-014-0618-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00380-014-0618-0" target="_blank" >10.1007/s00380-014-0618-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Correlations of the changes in bioptic findings with echocardiographic, clinical and laboratory parameters in patients with inflammatory cardiomyopathy

Popis výsledku v původním jazyce

Patients with myocarditis and left ventricular (LV) dysfunction may improve after standard heart failure therapy. This improvement seems to be related to retreat of myocardial inflammation. The aim of the present study was to assess changes in clinical, echocardiographic and some laboratory parameters and to correlate them with changes in the number of inflammatory infiltrating cells in endomyocardial biopsy (EMB) samples during the 6-month follow-up, and to define predictors of LV function improvement among baseline parameters. Forty patients with biopsy-proven myocarditis and impaired LV function (LV ejection fraction-LVEF <40 %) with heart failure symptoms LESS-THAN OR EQUAL TO6 months were evaluated. Myocarditis was defined as the presence of >14 mononuclear leukocytes/mm2 and/or >7 T-lymphocytes/mm2 in the baseline EMB. The EMB, echocardiography and clinical evaluation were repeated after 6 months of standard heart failure therapy. LVEF improved on average from 25 +- 9 to 42 +- 12 % (p < 0.001); LV end-systolic volume and LV end-diastolic volume (LVEDV) decreased from 158 +- 61 to 111 +- 58 ml and from 211 +- 69 to 178 +- 63 ml (both p < 0.001). NYHA class decreased from 2.6 +- 0.5 to 1.6 +- 0.6 (p < 0.001) and NTproBNP from 2892 +- 3227 to 851 +- 1835 µg/ml (p < 0.001). A decrease in the number of infiltrating leukocytes (CD45+/LCA+) from 23 +- 15 to 13 +- 8 cells/mm2 and in the number of infiltrating T lymphocytes (CD3+) from 7 +- 5 to 4 +- 3 cells/mm2 (both p < 0.001) was observed.

Název v anglickém jazyce

Correlations of the changes in bioptic findings with echocardiographic, clinical and laboratory parameters in patients with inflammatory cardiomyopathy

Popis výsledku anglicky

Patients with myocarditis and left ventricular (LV) dysfunction may improve after standard heart failure therapy. This improvement seems to be related to retreat of myocardial inflammation. The aim of the present study was to assess changes in clinical, echocardiographic and some laboratory parameters and to correlate them with changes in the number of inflammatory infiltrating cells in endomyocardial biopsy (EMB) samples during the 6-month follow-up, and to define predictors of LV function improvement among baseline parameters. Forty patients with biopsy-proven myocarditis and impaired LV function (LV ejection fraction-LVEF <40 %) with heart failure symptoms LESS-THAN OR EQUAL TO6 months were evaluated. Myocarditis was defined as the presence of >14 mononuclear leukocytes/mm2 and/or >7 T-lymphocytes/mm2 in the baseline EMB. The EMB, echocardiography and clinical evaluation were repeated after 6 months of standard heart failure therapy. LVEF improved on average from 25 +- 9 to 42 +- 12 % (p < 0.001); LV end-systolic volume and LV end-diastolic volume (LVEDV) decreased from 158 +- 61 to 111 +- 58 ml and from 211 +- 69 to 178 +- 63 ml (both p < 0.001). NYHA class decreased from 2.6 +- 0.5 to 1.6 +- 0.6 (p < 0.001) and NTproBNP from 2892 +- 3227 to 851 +- 1835 µg/ml (p < 0.001). A decrease in the number of infiltrating leukocytes (CD45+/LCA+) from 23 +- 15 to 13 +- 8 cells/mm2 and in the number of infiltrating T lymphocytes (CD3+) from 7 +- 5 to 4 +- 3 cells/mm2 (both p < 0.001) was observed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Heart and Vessels

ISSN

0910-8327

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

416-426

Kód UT WoS článku

000371803600017

EID výsledku v databázi Scopus

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