Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065537" target="_blank" >RIV/00159816:_____/16:00065537 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00090789

Výsledek na webu

<a href="http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=1371&type=fin&ver=3" target="_blank" >http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=1371&type=fin&ver=3</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Popis výsledku v původním jazyce

Aims: To compare the differences between patients with inflammatory cardiomyopathy (ICM) with and without improvement in left ventricular (LV) systolic function and to identify the relevant predictors of LV improvement. Patients and Methods: The study included 63 patients with biopsy-proven ICM and heart failure symptoms of at least NYHA II, symptom duration LESS-THAN OR EQUAL TO 6 months, LV ejection fraction (LVEF) LESS-THAN OR EQUAL TO 40% assessed by echocardiography and presence of >14 mononuclear leukocytes (LCA+ cells)/mm2 in biopsy samples. Patients were evaluated at baseline and after 6 months. Results: In the group with LVEF improvement of GREATER-THAN OR EQUAL TO 10% (I+ group, n = 41), LVEF increased from 24 +- 7% to 47 +- 8% (P < 0.001). In 22 patients (group I-), there was no or minimal LVEF increase (< 10%). In the I+ group, there were more LCA+ cells/mm2 at baseline (25.1 +- 16.5 vs. 18.5 +- 4.4 cells/mm2; P = 0.032) and a more significant decrease in LCA+ cells in the follow-up (reduction of 13.6 +- 14.3 cells/mm2 vs. 5.0 +- 7.7 cells/mm2 in the I- group; P = 0.009). The univariate logistic regression showed a possible association of number of LCA+ cells, LV end-diastolic diameter and N-terminal fragment of pro-brain natriuretic peptide (NTproBNP) value with LVEF improvement. In the multivariate analysis, only NTproBNP at diagnosis was confirmed as an independent predictor of LVEF improvement (OR=1.2; 1.003 to 1.394; P = 0.046). Conclusion: The LV systolic function improvement was observed in 65% of the patients. In these patients, the number of inflammatory cells at baseline was higher and decreased more but the higher baseline NTproBNP value was the only independent predictor of LVEF improvement.

Název v anglickém jazyce

Improvement of left ventricular systolic function in inflammatory cardiomyopathy: What plays a role?

Popis výsledku anglicky

Aims: To compare the differences between patients with inflammatory cardiomyopathy (ICM) with and without improvement in left ventricular (LV) systolic function and to identify the relevant predictors of LV improvement. Patients and Methods: The study included 63 patients with biopsy-proven ICM and heart failure symptoms of at least NYHA II, symptom duration LESS-THAN OR EQUAL TO 6 months, LV ejection fraction (LVEF) LESS-THAN OR EQUAL TO 40% assessed by echocardiography and presence of >14 mononuclear leukocytes (LCA+ cells)/mm2 in biopsy samples. Patients were evaluated at baseline and after 6 months. Results: In the group with LVEF improvement of GREATER-THAN OR EQUAL TO 10% (I+ group, n = 41), LVEF increased from 24 +- 7% to 47 +- 8% (P < 0.001). In 22 patients (group I-), there was no or minimal LVEF increase (< 10%). In the I+ group, there were more LCA+ cells/mm2 at baseline (25.1 +- 16.5 vs. 18.5 +- 4.4 cells/mm2; P = 0.032) and a more significant decrease in LCA+ cells in the follow-up (reduction of 13.6 +- 14.3 cells/mm2 vs. 5.0 +- 7.7 cells/mm2 in the I- group; P = 0.009). The univariate logistic regression showed a possible association of number of LCA+ cells, LV end-diastolic diameter and N-terminal fragment of pro-brain natriuretic peptide (NTproBNP) value with LVEF improvement. In the multivariate analysis, only NTproBNP at diagnosis was confirmed as an independent predictor of LVEF improvement (OR=1.2; 1.003 to 1.394; P = 0.046). Conclusion: The LV systolic function improvement was observed in 65% of the patients. In these patients, the number of inflammatory cells at baseline was higher and decreased more but the higher baseline NTproBNP value was the only independent predictor of LVEF improvement.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14087" target="_blank" >NT14087: Komplexní bioptická diagnostika zánětlivých a virových onemocnění myokardu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

160

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

524-532

Kód UT WoS článku

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EID výsledku v databázi Scopus

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