Impact of inflammatory infiltration and viral genome presence in myocardium on the changes of echocardiogrraphic parameters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209775%3A_____%2F13%3A%230000266" target="_blank" >RIV/00209775:_____/13:#0000266 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.crvasa.2013.02.003" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2013.02.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.crvasa.2013.02.003" target="_blank" >10.1016/j.crvasa.2013.02.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of inflammatory infiltration and viral genome presence in myocardium on the changes of echocardiogrraphic parameters

Popis výsledku v původním jazyce

Seventy patients with a recent occurrence of DCM with left ventricle ejection fraction (LVEF) <40% and with the history of symptoms less than 12 months were enrolled to observation. In EMB samples the average number of T-lymphocytes (CD3+ cells) and mononuclear leucocytes (LCA+ cells) in mm2 was determined. The presence of inflammation was evaluated as positive in case of the findings of >7 CD3+ cells and/or >14 LCA+ cells in mm2. The detection of pathological agents in myocardium was performed by quantitative PCR. According to immunohistological (IH) assessment findings were positive (IH+) in 35 patients (i.e. 50%); thus the inflammatory infiltration was present in myocardium. In remaining patients the findings were negative (IH-). At 6 months follow-up, in the group of IH+ patients the LVEF improved from 25+-9% to 39+-11% and NYHA class declined from 2.8+-0.5 to 1.7+-0.6 (both p<0.001). In IH- group change in LVEF (from 23+-8% to 27+-10%) in contrast to the change of NYHA class (from

Název v anglickém jazyce

Impact of inflammatory infiltration and viral genome presence in myocardium on the changes of echocardiogrraphic parameters

Popis výsledku anglicky

Seventy patients with a recent occurrence of DCM with left ventricle ejection fraction (LVEF) <40% and with the history of symptoms less than 12 months were enrolled to observation. In EMB samples the average number of T-lymphocytes (CD3+ cells) and mononuclear leucocytes (LCA+ cells) in mm2 was determined. The presence of inflammation was evaluated as positive in case of the findings of >7 CD3+ cells and/or >14 LCA+ cells in mm2. The detection of pathological agents in myocardium was performed by quantitative PCR. According to immunohistological (IH) assessment findings were positive (IH+) in 35 patients (i.e. 50%); thus the inflammatory infiltration was present in myocardium. In remaining patients the findings were negative (IH-). At 6 months follow-up, in the group of IH+ patients the LVEF improved from 25+-9% to 39+-11% and NYHA class declined from 2.8+-0.5 to 1.7+-0.6 (both p<0.001). In IH- group change in LVEF (from 23+-8% to 27+-10%) in contrast to the change of NYHA class (from

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

—

Svazek periodika

55

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

"E333"-"E340"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—