Prevalence and Clinical Significance of an E-Reversal Wave in the Left Ventricular Outflow Tract

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00065631" target="_blank" >RIV/00159816:_____/16:00065631 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.amjcard.2016.08.026" target="_blank" >http://dx.doi.org/10.1016/j.amjcard.2016.08.026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amjcard.2016.08.026" target="_blank" >10.1016/j.amjcard.2016.08.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence and Clinical Significance of an E-Reversal Wave in the Left Ventricular Outflow Tract

Popis výsledku v původním jazyce

Diastolic waves are commonly seen in the left ventricular outflow tract on echocardiography. This work focuses on the E-reversal wave (Er) that occurs early in diastole, shortly after the mitral E wave. Factors associated with Er presence and velocity were investigated in a broad patient sample: 100 subjects with normal ejection fraction (EF >55%) and 100 subjects with reduced EF (<45%). Er presence was noted in 58% of the total cohort and correlated inversely with age. It was more common with normal EF (70% vs 45%, p = 0.0005) and was associated with higher mitral E velocity (78.3 +- 23.3 vs 68.4 +- 19.0 cm/s; p = 0.002) and septal e' velocity (6.7 +- 2.5 vs 5.3 +- 2.3 cm/s; p <0.0001). Er velocity was higher in the normal EF group (50 +- 18 vs 34 +- 13 cm/s, p <0.0001) and showed moderate correlation with septal e' velocity (r = 0.43; p <0.0001); 56 subjects experienced major adverse cardiovascular events (MACE) over 1.7 +- 0.3 years of follow-up. Those with an Er had less MACE (particularly heart failure), even after adjustment for multiple clinical and echocardiographic variables (OR 0.28, 95% CI 0.11 to 0.65; p = 0.003). When stratified by EF, the association between Er presence and MACE was significant only in the low EF group. Thus, Er occurs more commonly in younger subjects and those with preserved EF. It is associated with less MACE although this effect appears to be limited to patients with reduced EF.

Název v anglickém jazyce

Prevalence and Clinical Significance of an E-Reversal Wave in the Left Ventricular Outflow Tract

Popis výsledku anglicky

Diastolic waves are commonly seen in the left ventricular outflow tract on echocardiography. This work focuses on the E-reversal wave (Er) that occurs early in diastole, shortly after the mitral E wave. Factors associated with Er presence and velocity were investigated in a broad patient sample: 100 subjects with normal ejection fraction (EF >55%) and 100 subjects with reduced EF (<45%). Er presence was noted in 58% of the total cohort and correlated inversely with age. It was more common with normal EF (70% vs 45%, p = 0.0005) and was associated with higher mitral E velocity (78.3 +- 23.3 vs 68.4 +- 19.0 cm/s; p = 0.002) and septal e' velocity (6.7 +- 2.5 vs 5.3 +- 2.3 cm/s; p <0.0001). Er velocity was higher in the normal EF group (50 +- 18 vs 34 +- 13 cm/s, p <0.0001) and showed moderate correlation with septal e' velocity (r = 0.43; p <0.0001); 56 subjects experienced major adverse cardiovascular events (MACE) over 1.7 +- 0.3 years of follow-up. Those with an Er had less MACE (particularly heart failure), even after adjustment for multiple clinical and echocardiographic variables (OR 0.28, 95% CI 0.11 to 0.65; p = 0.003). When stratified by EF, the association between Er presence and MACE was significant only in the low EF group. Thus, Er occurs more commonly in younger subjects and those with preserved EF. It is associated with less MACE although this effect appears to be limited to patients with reduced EF.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Cardiology

ISSN

0002-9149

e-ISSN

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Svazek periodika

118

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1593-1597

Kód UT WoS článku

000389015900026

EID výsledku v databázi Scopus

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