Mesenchymal Stem Cells Immune Properties As Sensors Of Microenvironment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00066036" target="_blank" >RIV/00159816:_____/16:00066036 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mesenchymal Stem Cells Immune Properties As Sensors Of Microenvironment

Popis výsledku v původním jazyce

Tissue inflammation leads to the recruitment and activation of several cell types, which cooperate to create a particular microenvironment that determines the regression of the pathology or its perpetuation (chronic inflammation). Mesenchymal stem cells (MSCs) are multipotent cells present in the stromal fraction of many tissues (i.e umbilical cord blood, placenta, adipose tissue). Several studies are now showing MSCs potential in tissue engineering, especially because of their ability to differentiate onto nanostructure surface. However the effect of nanostructure on MSCs immune properties is not properly characterized. The aim of the project is to develop MSCs reporter lines for transcription factors associated to inflammation, in order to monitor their activity once the cells are seeded onto nanostructure. This will be helpful to understand which materials are more suitable in term of tissue regeneration

Název v anglickém jazyce

Mesenchymal Stem Cells Immune Properties As Sensors Of Microenvironment

Popis výsledku anglicky

Tissue inflammation leads to the recruitment and activation of several cell types, which cooperate to create a particular microenvironment that determines the regression of the pathology or its perpetuation (chronic inflammation). Mesenchymal stem cells (MSCs) are multipotent cells present in the stromal fraction of many tissues (i.e umbilical cord blood, placenta, adipose tissue). Several studies are now showing MSCs potential in tissue engineering, especially because of their ability to differentiate onto nanostructure surface. However the effect of nanostructure on MSCs immune properties is not properly characterized. The aim of the project is to develop MSCs reporter lines for transcription factors associated to inflammation, in order to monitor their activity once the cells are seeded onto nanostructure. This will be helpful to understand which materials are more suitable in term of tissue regeneration

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/LQ1605" target="_blank" >LQ1605: Translační medicína</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

8TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH &amp; APPLICATION (NANOCON 2016)

ISBN

978-80-87294-71-0

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

4

Strana od-do

435-438

Název nakladatele

TANGER Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

19. 10. 2016

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000410656100076