Multivariate Analysis of Correspondence between Left Atrial Volumes Assessed by Echocardiography and 3-Dimensional Electroanatomic Mapping in Patients with Atrial Fibrillation

Kód výsledku v IS VaVaI

RIV/00159816:_____/16:00066246 - isvavai.cz

Nalezeny alternativní kódy

RIV/60076658:12110/16:43891885 RIV/00216224:14110/16:00093174 RIV/00216208:11110/16:10325313 RIV/65269705:_____/16:00066246 a 2 dalších

Výsledek na webu

http://dx.doi.org/10.1371/journal.pone.0152553

DOI - Digital Object Identifier

10.1371/journal.pone.0152553

Jazyk výsledku

angličtina

Název v původním jazyce

Multivariate Analysis of Correspondence between Left Atrial Volumes Assessed by Echocardiography and 3-Dimensional Electroanatomic Mapping in Patients with Atrial Fibrillation

Popis výsledku v původním jazyce

Background Left atrial (LA) enlargement is a predictor of worse outcome after catheter ablation for atrial fibrillation (AF). Widely used two-dimensional (2D)-echocardiography is inaccurate and underestimates real LA volume (LAV). We hypothesized that baseline clinical characteristics of patients can be used to adjust 2D-ECHO indices of LAV in order to minimize this disagreement. Methods The study enrolled 535 patients (59 +/- 9 years; 67% males; 43% paroxysmal AF) who underwent catheter ablation for AF in three specialized centers. We investigated multivariately the relationship between 2D-echocardiographic indices of LA size, specifically LA diameter in M-mode in the parasternal long-axis view (LAD), LAV assessed by the prolate-ellipsoid method (LAV(Ellipsoid)), LAV by the planimetric method (LAV(Planimetry)), and LAV derived from 3D-electroanatomic mapping (LAV(CARTO)). Results Cubed LAD of 106 +/- 45 ml, LAV(Ellipsoid) of 72 +/- 24 ml and LAV(Planimetry) of 88 +/- 30 ml correlated only modestly (r = 0.60, 0.69, and 0.53, respectively) with LAV(CARTO) of 137 +/- 46 ml, which was significantly underestimated with a bias (+/- 1.96 standard deviation) of -31 (-111; +49) ml, -64(-132; +2) ml, and -49(-125; +27) ml, respectively; p < 0.0001 for their mutual difference. LA enlargement itself, age, gender, type of AF, and the presence of structural heart disease were independent confounders of measurement error of 2D-echocardiographic LAV. Conclusion Accuracy and precision of all 2D-echocardiographic LAV indices are poor. Their agreement with true LAV can be significantly improved by multivariate adjustment to clinical characteristics of patients.

Název v anglickém jazyce

Multivariate Analysis of Correspondence between Left Atrial Volumes Assessed by Echocardiography and 3-Dimensional Electroanatomic Mapping in Patients with Atrial Fibrillation

Popis výsledku anglicky

Background Left atrial (LA) enlargement is a predictor of worse outcome after catheter ablation for atrial fibrillation (AF). Widely used two-dimensional (2D)-echocardiography is inaccurate and underestimates real LA volume (LAV). We hypothesized that baseline clinical characteristics of patients can be used to adjust 2D-ECHO indices of LAV in order to minimize this disagreement. Methods The study enrolled 535 patients (59 +/- 9 years; 67% males; 43% paroxysmal AF) who underwent catheter ablation for AF in three specialized centers. We investigated multivariately the relationship between 2D-echocardiographic indices of LA size, specifically LA diameter in M-mode in the parasternal long-axis view (LAD), LAV assessed by the prolate-ellipsoid method (LAV(Ellipsoid)), LAV by the planimetric method (LAV(Planimetry)), and LAV derived from 3D-electroanatomic mapping (LAV(CARTO)). Results Cubed LAD of 106 +/- 45 ml, LAV(Ellipsoid) of 72 +/- 24 ml and LAV(Planimetry) of 88 +/- 30 ml correlated only modestly (r = 0.60, 0.69, and 0.53, respectively) with LAV(CARTO) of 137 +/- 46 ml, which was significantly underestimated with a bias (+/- 1.96 standard deviation) of -31 (-111; +49) ml, -64(-132; +2) ml, and -49(-125; +27) ml, respectively; p < 0.0001 for their mutual difference. LA enlargement itself, age, gender, type of AF, and the presence of structural heart disease were independent confounders of measurement error of 2D-echocardiographic LAV. Conclusion Accuracy and precision of all 2D-echocardiographic LAV indices are poor. Their agreement with true LAV can be significantly improved by multivariate adjustment to clinical characteristics of patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

"e0152553"

Kód UT WoS článku

000373113900075

EID výsledku v databázi Scopus

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