Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F16%3A00068461" target="_blank" >RIV/00159816:_____/16:00068461 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/08037051.2015.1121708" target="_blank" >http://dx.doi.org/10.3109/08037051.2015.1121708</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/08037051.2015.1121708" target="_blank" >10.3109/08037051.2015.1121708</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension

Popis výsledku v původním jazyce

Prehypertension is associated with increased cardiovascular events. While the tracking phenomenon is an important longitudinal characteristic of blood pressure (BP), changes in muscle sympathetic nerve activity (MSNA) over time remain unclear. This study tested the hypothesis that MSNA tracking contributes to BP trends in prehypertension. BP and MSNA were assessed in 13 prehypertensive males at rest, during hand grip and mental stressors at baseline and after 8 years. Baseline office BP averaged 127 +/- 2/81 +/- 2 mmHg and MSNA 24 +/- 4 bursts/min. BP increased by 7 +/- 2/5 +/- 2 mmHg (P&lt;0.01) and MSNA by 11 +/- 2 bursts/min (P&lt;0.001) at follow-up. SBP and DBP were interrelated at baseline (r=0.65, P=0.02) and at follow-up (r=0.78, P=0.002). MSNA tracking (r=0.82; P&lt;0.001) was similar to BP. MSNA was strongly related to DBP at baseline (r=0.73; P&lt;0.01) and follow-up (r=0.64; P=0.01), more so than SBP. BMI increased (P&lt;0.001) at follow-up but was unrelated to BP or MSNA. Despite comparable pressor and cardiac increases to handgrip and mental stressors, sympathetic responses were blunted, more pronounced to isometric test (P&lt;0.006) at follow-up. In conclusion, the trend in MSNA corresponds with BP changes over time suggesting that tonic sympathetic activation may contribute to time-related increase in resting BP and the development of sustained hypertension in prehypertension.

Název v anglickém jazyce

Longitudinal tracking of muscle sympathetic nerve activity and its relationship with blood pressure in subjects with prehypertension

Popis výsledku anglicky

Prehypertension is associated with increased cardiovascular events. While the tracking phenomenon is an important longitudinal characteristic of blood pressure (BP), changes in muscle sympathetic nerve activity (MSNA) over time remain unclear. This study tested the hypothesis that MSNA tracking contributes to BP trends in prehypertension. BP and MSNA were assessed in 13 prehypertensive males at rest, during hand grip and mental stressors at baseline and after 8 years. Baseline office BP averaged 127 +/- 2/81 +/- 2 mmHg and MSNA 24 +/- 4 bursts/min. BP increased by 7 +/- 2/5 +/- 2 mmHg (P&lt;0.01) and MSNA by 11 +/- 2 bursts/min (P&lt;0.001) at follow-up. SBP and DBP were interrelated at baseline (r=0.65, P=0.02) and at follow-up (r=0.78, P=0.002). MSNA tracking (r=0.82; P&lt;0.001) was similar to BP. MSNA was strongly related to DBP at baseline (r=0.73; P&lt;0.01) and follow-up (r=0.64; P=0.01), more so than SBP. BMI increased (P&lt;0.001) at follow-up but was unrelated to BP or MSNA. Despite comparable pressor and cardiac increases to handgrip and mental stressors, sympathetic responses were blunted, more pronounced to isometric test (P&lt;0.006) at follow-up. In conclusion, the trend in MSNA corresponds with BP changes over time suggesting that tonic sympathetic activation may contribute to time-related increase in resting BP and the development of sustained hypertension in prehypertension.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Blood pressure

ISSN

0803-7051

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

184-192

Kód UT WoS článku

000377030300009

EID výsledku v databázi Scopus

—