Nocturnal Dynamics of Sleep-Wake Transitions in Patients With Narcolepsy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067032" target="_blank" >RIV/00159816:_____/17:00067032 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1093/sleep/zsw050" target="_blank" >http://dx.doi.org/10.1093/sleep/zsw050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/sleep/zsw050" target="_blank" >10.1093/sleep/zsw050</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nocturnal Dynamics of Sleep-Wake Transitions in Patients With Narcolepsy

Popis výsledku v původním jazyce

Introduction: We investigate how characteristics of sleep-wake dynamics in humans are modified by narcolepsy, a clinical condition that is supposed to destabilize sleep-wake regulation. Subjects with and without cataplexy are considered separately. Differences in sleep scoring habits as a possible confounder have been examined. Aims and Methods: Four groups of subjects are considered: narcolepsy patients from China with (n = 88) and without (n = 15) cataplexy, healthy controls from China (n = 110) and from Europe (n = 187, 2 nights each). After sleep-stage scoring and calculation of sleep characteristic parameters, the distributions of wake-episode durations and sleep-episode durations are determined for each group and fitted by power laws (exponent a) and by exponentials (decay time tau). Results: We find that wake duration distributions are consistent with power laws for healthy subjects (China: alpha = 0.88, Europe: alpha = 1.02). Wake durations in all groups of narcolepsy patients, however, follow the exponential law (tau = 6.2-8.1 min). All sleep duration distributions are best fitted by exponentials on long time scales (tau = 34-82 min). Conclusions: We conclude that narcolepsy mainly alters the control of wake-episode durations but not sleep-episode durations, irrespective of cataplexy. Observed distributions of shortest wake and sleep durations suggest that differences in scoring habits regarding the scoring of short-term sleep stages may notably influence the fitting parameters but do not affect the main conclusion.

Název v anglickém jazyce

Nocturnal Dynamics of Sleep-Wake Transitions in Patients With Narcolepsy

Popis výsledku anglicky

Introduction: We investigate how characteristics of sleep-wake dynamics in humans are modified by narcolepsy, a clinical condition that is supposed to destabilize sleep-wake regulation. Subjects with and without cataplexy are considered separately. Differences in sleep scoring habits as a possible confounder have been examined. Aims and Methods: Four groups of subjects are considered: narcolepsy patients from China with (n = 88) and without (n = 15) cataplexy, healthy controls from China (n = 110) and from Europe (n = 187, 2 nights each). After sleep-stage scoring and calculation of sleep characteristic parameters, the distributions of wake-episode durations and sleep-episode durations are determined for each group and fitted by power laws (exponent a) and by exponentials (decay time tau). Results: We find that wake duration distributions are consistent with power laws for healthy subjects (China: alpha = 0.88, Europe: alpha = 1.02). Wake durations in all groups of narcolepsy patients, however, follow the exponential law (tau = 6.2-8.1 min). All sleep duration distributions are best fitted by exponentials on long time scales (tau = 34-82 min). Conclusions: We conclude that narcolepsy mainly alters the control of wake-episode durations but not sleep-episode durations, irrespective of cataplexy. Observed distributions of shortest wake and sleep durations suggest that differences in scoring habits regarding the scoring of short-term sleep stages may notably influence the fitting parameters but do not affect the main conclusion.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sleep

ISSN

1550-9109

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"zsw050"

Kód UT WoS článku

000394129900013

EID výsledku v databázi Scopus

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