Cardiovascular fitness in narcolepsy is inversely related to sleepiness and the number of cataplexy episodes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064165%3A_____%2F17%3A10360823" target="_blank" >RIV/00064165:_____/17:10360823 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10360823

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.sleep.2017.02.017" target="_blank" >http://dx.doi.org/10.1016/j.sleep.2017.02.017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.sleep.2017.02.017" target="_blank" >10.1016/j.sleep.2017.02.017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiovascular fitness in narcolepsy is inversely related to sleepiness and the number of cataplexy episodes

Popis výsledku v původním jazyce

Objective: Cardiopulmonary fitness depends on daily energy expenditure or the amount of daily exercise. Patients with narcolepsy spent more time being sleepy or asleep than controls; thus we may speculate that they have a lower quantity and quality of physical activity. The aim of the present study was thus to test the hypothesis that exercise tolerance in narcolepsy negatively depends on sleepiness. Patients and methods: The cross-sectional study included 32 patients with narcolepsy with cataplexy, 10 patients with narcolepsy without cataplexy, and 36 age-and gender-matched control subjects, in whom a symptom-limited exercise stress test with expired gas analysis was performed. A linear regression analysis with multivariate models was used with stepwise variable selection. Results: In narcolepsy patients, maximal oxygen uptake (VO2peak) was 30.1 +/- 7.5 mL/kg/min, which was lower than 36.0 +/- 7.8 mL/kg/min, p = 0.001, in controls and corresponded to 86.4% +/- 20.0% of the population norm (VO2peak%) and to a standard deviation (VO2peakSD) of -1.08 +/- 1.63 mL/kg/min of the population norm. VO2peak depended primarily on gender (p = 0.007) and on sleepiness (p = 0.046). VO2peak% depended on sleepiness (p = 0.028) and on age (p = 0.039). VO2peakSD depended on the number of cataplexy episodes per month (p = 0.015) and on age (p = 0.030). Conclusions: Cardiopulmonary fitness in narcolepsy and in narcolepsy without cataplexy is inversely related to the degree of sleepiness and cataplexy episode frequency.

Název v anglickém jazyce

Cardiovascular fitness in narcolepsy is inversely related to sleepiness and the number of cataplexy episodes

Popis výsledku anglicky

Objective: Cardiopulmonary fitness depends on daily energy expenditure or the amount of daily exercise. Patients with narcolepsy spent more time being sleepy or asleep than controls; thus we may speculate that they have a lower quantity and quality of physical activity. The aim of the present study was thus to test the hypothesis that exercise tolerance in narcolepsy negatively depends on sleepiness. Patients and methods: The cross-sectional study included 32 patients with narcolepsy with cataplexy, 10 patients with narcolepsy without cataplexy, and 36 age-and gender-matched control subjects, in whom a symptom-limited exercise stress test with expired gas analysis was performed. A linear regression analysis with multivariate models was used with stepwise variable selection. Results: In narcolepsy patients, maximal oxygen uptake (VO2peak) was 30.1 +/- 7.5 mL/kg/min, which was lower than 36.0 +/- 7.8 mL/kg/min, p = 0.001, in controls and corresponded to 86.4% +/- 20.0% of the population norm (VO2peak%) and to a standard deviation (VO2peakSD) of -1.08 +/- 1.63 mL/kg/min of the population norm. VO2peak depended primarily on gender (p = 0.007) and on sleepiness (p = 0.046). VO2peak% depended on sleepiness (p = 0.028) and on age (p = 0.039). VO2peakSD depended on the number of cataplexy episodes per month (p = 0.015) and on age (p = 0.030). Conclusions: Cardiopulmonary fitness in narcolepsy and in narcolepsy without cataplexy is inversely related to the degree of sleepiness and cataplexy episode frequency.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NT13238" target="_blank" >NT13238: Narkolepsie – klinika, patofyziologie, stárnutí, komorbidity a pohybový režim.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Sleep Medicine

ISSN

1389-9457

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

7-12

Kód UT WoS článku

000402353400002

EID výsledku v databázi Scopus

2-s2.0-85016743835