Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10329361" target="_blank" >RIV/00216208:11110/17:10329361 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/17:10329361

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/66/66_41.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/66/66_41.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Popis výsledku v původním jazyce

Hypokalemia as a typical feature of primary aldosteronism (PA) is associated with muscle weakness and could contribute to lower cardiopulmonary fitness. The aim of this study was to describe cardiopulmonary fitness and exercise blood pressure and their determinants during a symptom-limited exercise stress test in patients with PA. We performed a cross-sectional study of patients with confirmed PA who were included before adrenal vein sampling on whom a symptom-limited exercise stress test with expired gas analysis was performed. Patients were switched to the treatment with doxazosin and verapamil at least two weeks before the study. In 27 patients (17 male) the VO2peak was 25.4 +/- 6.0 ml/ kg/min which corresponds to 80.8 +/- 18.9 % of Czech national norm. Linear regression analysis shows that VO2peak depends on doxazosin dose (DX) (p= 0.001) and kalemia (p= 0.02): VO2peak = 4.2-1.0 * DX + 7.6 * Kalemia. Patients with higher doxazosin doses had a longer history of hypertension and had used more antihypertensives before examination, thus indicating that VO2peak also depends on the severity of hypertension. In patients with PA, lower cardiopulmonary fitness depends inversely on the severity of hypertension and on lower plasma potassium level.

Název v anglickém jazyce

Lower Physical Fitness in Patients With Primary Aldosteronism Is Linked to the Severity of Hypertension and Kalemia

Popis výsledku anglicky

Hypokalemia as a typical feature of primary aldosteronism (PA) is associated with muscle weakness and could contribute to lower cardiopulmonary fitness. The aim of this study was to describe cardiopulmonary fitness and exercise blood pressure and their determinants during a symptom-limited exercise stress test in patients with PA. We performed a cross-sectional study of patients with confirmed PA who were included before adrenal vein sampling on whom a symptom-limited exercise stress test with expired gas analysis was performed. Patients were switched to the treatment with doxazosin and verapamil at least two weeks before the study. In 27 patients (17 male) the VO2peak was 25.4 +/- 6.0 ml/ kg/min which corresponds to 80.8 +/- 18.9 % of Czech national norm. Linear regression analysis shows that VO2peak depends on doxazosin dose (DX) (p= 0.001) and kalemia (p= 0.02): VO2peak = 4.2-1.0 * DX + 7.6 * Kalemia. Patients with higher doxazosin doses had a longer history of hypertension and had used more antihypertensives before examination, thus indicating that VO2peak also depends on the severity of hypertension. In patients with PA, lower cardiopulmonary fitness depends inversely on the severity of hypertension and on lower plasma potassium level.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

41-48

Kód UT WoS článku

000398620000004

EID výsledku v databázi Scopus

2-s2.0-85017106165