The Effect of Adrenalectomy on Exercise Response of the Renin-Angiotensin-Aldosterone System and Exercise Tolerance in Primary Aldosteronism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376470" target="_blank" >RIV/00216208:11110/18:10376470 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/18:10376470

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/67/67_233.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/67/67_233.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Adrenalectomy on Exercise Response of the Renin-Angiotensin-Aldosterone System and Exercise Tolerance in Primary Aldosteronism

Popis výsledku v původním jazyce

Primary aldosteronism (PA) is associated with objectively measured lower physical fitness and blunted response of the renin-angiotensin-aldosterone system to exercise. The purpose of this pilot study was to objectively measure exercise response of the renin-angiotensin-aldosterone system and cardiopulmonary fitness changes after laparoscopic adrenalectomy (ADE) in patients with unilateral PA. We examined a total of 14 patients with confirmed PA before and after ADE, by means of spiroergometry and hormonal evaluation. As expected, after adrenalectomy basal aldosterone (Aldo) levels before exercise decreased significantly, with a concomitant increase in plasma renin (PR). The increase in Aldo (285.9 +/- 171.3 to 434.1 +/- 278.2 ng/l; p=0.02) and blunted increase in PR (7.1 +/- 0.4 to 8.9 +/- 10.4 pg/ml; NS) post-exercise before ADE became significant after ADE Aldo post-ADE (46.8 +/- 18.8 to 106.5 +/- 68.1 ng/l; p&lt;0.0001) and PR post-ADE (20.1 +/- 14.5 to 33.9 +/- 30.7 pg/ml; p=0.014). After adrenalectomy, the patients had a non-significant increase in peak workload and VO2peak. We found normalization of the renin-angiotensin-aldosterone system response to exercise with little changes in cardiopulmonary fitness six months after ADE.

Název v anglickém jazyce

The Effect of Adrenalectomy on Exercise Response of the Renin-Angiotensin-Aldosterone System and Exercise Tolerance in Primary Aldosteronism

Popis výsledku anglicky

Primary aldosteronism (PA) is associated with objectively measured lower physical fitness and blunted response of the renin-angiotensin-aldosterone system to exercise. The purpose of this pilot study was to objectively measure exercise response of the renin-angiotensin-aldosterone system and cardiopulmonary fitness changes after laparoscopic adrenalectomy (ADE) in patients with unilateral PA. We examined a total of 14 patients with confirmed PA before and after ADE, by means of spiroergometry and hormonal evaluation. As expected, after adrenalectomy basal aldosterone (Aldo) levels before exercise decreased significantly, with a concomitant increase in plasma renin (PR). The increase in Aldo (285.9 +/- 171.3 to 434.1 +/- 278.2 ng/l; p=0.02) and blunted increase in PR (7.1 +/- 0.4 to 8.9 +/- 10.4 pg/ml; NS) post-exercise before ADE became significant after ADE Aldo post-ADE (46.8 +/- 18.8 to 106.5 +/- 68.1 ng/l; p&lt;0.0001) and PR post-ADE (20.1 +/- 14.5 to 33.9 +/- 30.7 pg/ml; p=0.014). After adrenalectomy, the patients had a non-significant increase in peak workload and VO2peak. We found normalization of the renin-angiotensin-aldosterone system response to exercise with little changes in cardiopulmonary fitness six months after ADE.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

67

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

233-238

Kód UT WoS článku

000431452400009

EID výsledku v databázi Scopus

2-s2.0-85046704645