Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067533" target="_blank" >RIV/00159816:_____/17:00067533 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00098773 RIV/65269705:_____/17:00067533

Výsledek na webu

<a href="http://dx.doi.org/10.1002/mds.26930" target="_blank" >http://dx.doi.org/10.1002/mds.26930</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mds.26930" target="_blank" >10.1002/mds.26930</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Popis výsledku v původním jazyce

Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society

Název v anglickém jazyce

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Popis výsledku anglicky

Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Movement disorders

ISSN

0885-3185

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

757-768

Kód UT WoS článku

000401936200018

EID výsledku v databázi Scopus

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