Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F17%3A00067727" target="_blank" >RIV/00159816:_____/17:00067727 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00095689

Výsledek na webu

<a href="https://www.termedia.pl/Terminally-differentiated-memory-T-cells-are-increased-in-patients-with-common-variable-immunodeficiency-and-selective-IgA-deficiency,10,30868,1,1.html" target="_blank" >https://www.termedia.pl/Terminally-differentiated-memory-T-cells-are-increased-in-patients-with-common-variable-immunodeficiency-and-selective-IgA-deficiency,10,30868,1,1.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/ceji.2017.70966" target="_blank" >10.5114/ceji.2017.70966</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

Popis výsledku v původním jazyce

Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder-selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naive CD45RO(-)CD27(+), early differentiated CD45RO(+)CD27(+), late differentiated CD45RO(+) CD27(-)and fully differentiated effector CD45RO(-)CD27(-)memory T cells, as well as Treg cells, defined as CD4(+) CD25highCD127 low T cells. Results: An increase of CD4(+) and CD8(+) late differentiated memory cells was observed comparing CVID patients to controls, as well as comparing IgAD patients to controls. In CVID patients an increase of CD4(+) early differentiated memory cells, a decrease of CD8(+) intermediate memory cells, and CD4(+) and CD8(+) naive cells were found as well. The abnormalities in IgAD patients might be explained by higher CMV seropositivity observed in our IgAD. We confirmed the repeatedly published decrease of Treg cells in CVID patients, while Treg cells in IgAD patients were increased compared to controls. Conclusions: Our results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.

Název v anglickém jazyce

Terminally differentiated memory T cells are increased in patients with common variable immunodeficiency and selective IgA deficiency

Popis výsledku anglicky

Introduction: Previous studies showed that several lymphocyte abnormalities seen in the most frequent symptomatic immunoglobulin deficiency, common variable immunodeficiency (CVID), were also observed in a genetically related asymptomatic disorder-selective IgA deficiency (IgAD). In this study we searched for abnormalities in the differentiation stages of T cells as well as for similarities of these abnormalities in CVID and IgAD patients. Material and methods: Using flow cytometry in 80 patients with IgAD, 48 patients with CVID, and 80 control persons we determined T-lymphocyte subsets: both CD4 and CD8 were divided into the naive CD45RO(-)CD27(+), early differentiated CD45RO(+)CD27(+), late differentiated CD45RO(+) CD27(-)and fully differentiated effector CD45RO(-)CD27(-)memory T cells, as well as Treg cells, defined as CD4(+) CD25highCD127 low T cells. Results: An increase of CD4(+) and CD8(+) late differentiated memory cells was observed comparing CVID patients to controls, as well as comparing IgAD patients to controls. In CVID patients an increase of CD4(+) early differentiated memory cells, a decrease of CD8(+) intermediate memory cells, and CD4(+) and CD8(+) naive cells were found as well. The abnormalities in IgAD patients might be explained by higher CMV seropositivity observed in our IgAD. We confirmed the repeatedly published decrease of Treg cells in CVID patients, while Treg cells in IgAD patients were increased compared to controls. Conclusions: Our results show T-cell activation not only in CVID, but also in IgAD patients. The increase in IgAD patients may be influenced by a more frequent CMV infection in our group of IgAD patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Immunology

ISSN

1426-3912

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

8

Strana od-do

244-251

Kód UT WoS článku

000415131100004

EID výsledku v databázi Scopus

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