T-lymphocyte subsets and function in IgA deficiency

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00006090" target="_blank" >RIV/00216224:14110/01:00006090 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

T-lymphocyte subsets and function in IgA deficiency

Popis výsledku v původním jazyce

Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this studywas to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyteproliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient,

Název v anglickém jazyce

T-lymphocyte subsets and function in IgA deficiency

Popis výsledku anglicky

Common variable immunodeficiency (CVID) and IgA deficiency (IgAD) are primary humoral immune deficiencies with probably similar genetic background, but clinical and laboratory manifestation is much more severe in CVID than in IgAD. The aim of this studywas to determine whether some abnormalities in T-lymphocyte subsets or function previously observed in CVID are also present in IgAD patients. T-lymphocyte subsets (CD3, CD4, CD8, CD4CD45RA, CD4CD45RO, CD8CD57) were studied in 61 adult IgAD patients and43 control healthy persons. A significant decrease in CD4+ and increase in CD8+ and CD8+CD57+ lymphocytes was observed, while no significant changes in the proportion of CD45RA+ or CD45RO+ in CD4 cells were detected. No significant changes in lymphocyteproliferation after stimulation with Phytohaemagglutinin, Concanavalin-A or tetanic toxoid were observed in 15 adult IgAD patients compared to 15 controls. Our study shows, that T-lymphocyte abnormalities are also present in IgAD patient,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NI4703" target="_blank" >NI4703: Poruchy imunoregulace u nemocných s humorálními imunodeficity</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scripta Medica

ISSN

12113395

e-ISSN

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Svazek periodika

74

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

345

Kód UT WoS článku

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EID výsledku v databázi Scopus

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