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Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068741" target="_blank" >RIV/00159816:_____/18:00068741 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216224:14110/18:00103600 RIV/00843989:_____/18:E0106883

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1016/j.seizure.2017.12.004" target="_blank" >http://dx.doi.org/10.1016/j.seizure.2017.12.004</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.seizure.2017.12.004" target="_blank" >10.1016/j.seizure.2017.12.004</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

  • Popis výsledku v původním jazyce

    Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient&apos;s history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient&apos;s history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.

  • Název v anglickém jazyce

    Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

  • Popis výsledku anglicky

    Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient&apos;s history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient&apos;s history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30210 - Clinical neurology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Seizure-European Journal of Epilepsy

  • ISSN

    1059-1311

  • e-ISSN

  • Svazek periodika

    54

  • Číslo periodika v rámci svazku

    JAN 2018

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    7

  • Strana od-do

    51-57

  • Kód UT WoS článku

    000424854100009

  • EID výsledku v databázi Scopus

    2-s2.0-85038217795