Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00068741" target="_blank" >RIV/00159816:_____/18:00068741 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00103600 RIV/00843989:_____/18:E0106883

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.seizure.2017.12.004" target="_blank" >http://dx.doi.org/10.1016/j.seizure.2017.12.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seizure.2017.12.004" target="_blank" >10.1016/j.seizure.2017.12.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

Popis výsledku v původním jazyce

Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient&apos;s history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient&apos;s history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.

Název v anglickém jazyce

Morphological changes of cerebellar substructures in temporal lobe epilepsy: A complex phenomenon, not mere atrophy

Popis výsledku anglicky

Purpose: To evaluate cerebellar volume changes in temporal lobe epilepsy (TLE) patients in greater detail. We aimed to determine which discrete substructures significantly differ in patients with TLE compared to controls and the nature of this difference. Correlations with age at epilepsy onset, epilepsy duration, seizure frequency, and total number of antiepileptic drugs (AED) in the patient&apos;s history were studied. We analyzed the potential association between cerebellar atrophy and epilepsy surgery outcome. Methods: Study participants were 36 TLE patients; 22 hippocampal sclerosis (HS) only and 38 healthy controls. All patients later underwent temporal lobe resection. All subjects were examined using 1.5T MRI. Cerebellar volume was adjusted for total intracranial volume, age, and gender, and measured using voxel-based morphometry. Cerebellar substructures were defined using the AAL atlas. Data processing was performed automatically. Separate analyses for HS only subset were performed. Results: Total cerebellar gray matter volume (GMV) appeared non-significantly smaller in epilepsy patients. Within the substructures, the GMV of the selected vermian segments were significantly larger in patients. The GMV of the whole cerebellum and of all individual cerebellar substructures non significantly decreased with increasing complex partial seizure frequency and total number of AEDs in the patient&apos;s history. Total cerebellar GMV was significantly smaller in patients with persistent seizures after epilepsy surgery than in seizure-free patients. Conclusion: Cerebellar atrophy is a complex phenomenon, the character of changes differs significantly within the cerebellar substructures. Total cerebellar GMV reduction is associated with worse outcome of temporal lobe resection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Seizure-European Journal of Epilepsy

ISSN

1059-1311

e-ISSN

—

Svazek periodika

54

Číslo periodika v rámci svazku

JAN 2018

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

51-57

Kód UT WoS článku

000424854100009

EID výsledku v databázi Scopus

2-s2.0-85038217795