Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00073203" target="_blank" >RIV/00159816:_____/20:00073203 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/20:00116365 RIV/00843989:_____/20:E0108537

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S1525505020303590?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1525505020303590?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.yebeh.2020.107180" target="_blank" >10.1016/j.yebeh.2020.107180</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Popis výsledku v původním jazyce

Purpose: The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods: The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results: Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermin and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion: There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLEHS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus. (C) 2020 Elsevier Inc. All rights reserved.

Název v anglickém jazyce

Cerebrocerebellar structural covariance in temporal lobe epilepsy with hippocampal sclerosis

Popis výsledku anglicky

Purpose: The purpose of the study was to evaluate cerebral morphological changes in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and their relationship to the cerebellum. Methods: The study cohort included 21 patients with intractable TLE-HS (14 left-sided, 7 right-sided) and 38 healthy controls (HC). All patients later underwent anteromedial temporal lobe resection. All subjects were examined using a 1.5-T magnetic resonance imaging (MRI). Volumes of distinct cerebral and cerebellar structures were measured using voxel-based morphometry. The structural covariance of temporal lobe structures, insula, and thalamus with cerebellar substructures was examined using partial least squares regression. Results: Morphological changes were more significant in the group with left TLE-HS when comparing left-sided with right-sided structures as well as when comparing patients with controls. The gray matter volume (GMV) of the temporal lobe structures was smaller ipsilaterally to the seizure onset side in most cases. There was a significant amygdala enlargement contralateral to the side of hippocampal sclerosis in both patients with right and left TLE-HS as compared with controls. Selected vermian structures in patients with left but not right TLE-HS had significantly larger GMV than the identical substructures in controls. The structural covariance differed significantly between patients with left and right TLE-HS as compared with HC. The analysis revealed significant negative covariance between anterior vermin and mesial temporal structures in the group with left TLE-HS. No significance was observed for the group with right TLE-HS. Conclusion: There is significant asymmetry in the GMV of cerebral and cerebellar structures in patients with TLEHS. Morphological changes are distinctly more pronounced in patients with left TLE-HS. The observed structural covariance between the cerebellum and supratentorial structures in TLE-HS suggests associations beyond the mesial temporal lobe structures and thalamus. (C) 2020 Elsevier Inc. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epilepsy &amp; Behavior

ISSN

1525-5050

e-ISSN

—

Svazek periodika

111

Číslo periodika v rámci svazku

OCT 2020

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

107180

Kód UT WoS článku

000577327900017

EID výsledku v databázi Scopus

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