Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069047" target="_blank" >RIV/00159816:_____/18:00069047 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00106369 RIV/65269705:_____/18:00069047

Výsledek na webu

<a href="https://www.termedia.pl/Neovascularization-after-ischemic-conditioning-of-the-stomach-and-the-influence-of-follow-up-neoadjuvant-chemotherapy-thereon,42,32837,1,1.html" target="_blank" >https://www.termedia.pl/Neovascularization-after-ischemic-conditioning-of-the-stomach-and-the-influence-of-follow-up-neoadjuvant-chemotherapy-thereon,42,32837,1,1.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/wiitm.2018.75907" target="_blank" >10.5114/wiitm.2018.75907</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon

Popis výsledku v původním jazyce

Introduction: Esophagectomy and reconstruction remain the optimal treatment for patients with resectable esophageal cancer. Neovascularization after ischemic conditioning of the stomach before esophagectomy is a laparoscopic procedure which may potentially reduce gastric conduit ischemia. Aim: To investigate the influence of ischemic conditioning on neovascularization along the greater curvature of the stomach and to explore the effect of neoadjuvant chemotherapy on neovascularization after ischemic conditioning. Material and methods: Staging laparoscopy was performed before the main resection procedure; during this procedure ischemic conditioning was performed. Samples taken from the human stomach were divided into 3 groups: group A - patients after ischemic conditioning with a delay of 30-45 days after left gastric artery (LGA) ligation (n = 4); group B - patients who were undergoing neoadjuvant chemotherapy with a delay of 90-140 days after left gastric artery ligation (n = 4); and control group C- patients without ischemic conditioning (n = 7). Results: After ischemic conditioning with a delay of 30-45 days, the count of neovessels along the greater curvature of the stomach increased from 5.4 +/- 0.7 in the control group to 17.5 +/- 0.9 in a low-power field of view (LPF) in group A and increased still further on average to 19.8 +/- 10.4 in group B. Conclusions: Left gastric artery ligation only is a sufficient procedure for ischemic conditioning of the stomach. Neovascularization along the greater curvature is a continuous process that depends on delay time. Neoadjuvant therapy has no influence on the effect of neovascularization.

Název v anglickém jazyce

Neovascularization after ischemic conditioning of the stomach and the influence of follow-up neoadjuvant chemotherapy thereon

Popis výsledku anglicky

Introduction: Esophagectomy and reconstruction remain the optimal treatment for patients with resectable esophageal cancer. Neovascularization after ischemic conditioning of the stomach before esophagectomy is a laparoscopic procedure which may potentially reduce gastric conduit ischemia. Aim: To investigate the influence of ischemic conditioning on neovascularization along the greater curvature of the stomach and to explore the effect of neoadjuvant chemotherapy on neovascularization after ischemic conditioning. Material and methods: Staging laparoscopy was performed before the main resection procedure; during this procedure ischemic conditioning was performed. Samples taken from the human stomach were divided into 3 groups: group A - patients after ischemic conditioning with a delay of 30-45 days after left gastric artery (LGA) ligation (n = 4); group B - patients who were undergoing neoadjuvant chemotherapy with a delay of 90-140 days after left gastric artery ligation (n = 4); and control group C- patients without ischemic conditioning (n = 7). Results: After ischemic conditioning with a delay of 30-45 days, the count of neovessels along the greater curvature of the stomach increased from 5.4 +/- 0.7 in the control group to 17.5 +/- 0.9 in a low-power field of view (LPF) in group A and increased still further on average to 19.8 +/- 10.4 in group B. Conclusions: Left gastric artery ligation only is a sufficient procedure for ischemic conditioning of the stomach. Neovascularization along the greater curvature is a continuous process that depends on delay time. Neoadjuvant therapy has no influence on the effect of neovascularization.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Videosurgery and Other Miniinvasive Techniques

ISSN

1895-4588

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

7

Strana od-do

299-305

Kód UT WoS článku

000443453800004

EID výsledku v databázi Scopus

2-s2.0-85053246547