Feasibility of directional percutaneous epicardial ablation with a partially insulated catheter

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069255" target="_blank" >RIV/00159816:_____/18:00069255 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/18:43878392

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10840-018-0404-5" target="_blank" >http://dx.doi.org/10.1007/s10840-018-0404-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10840-018-0404-5" target="_blank" >10.1007/s10840-018-0404-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Feasibility of directional percutaneous epicardial ablation with a partially insulated catheter

Popis výsledku v původním jazyce

PurposeTo demonstrate the feasibility of directional percutaneous epicardial ablation using a partially insulated catheter.MethodsPartially insulated catheter prototypes were tested in 12 (6 canine, 6 porcine) animal studies in two centers. Prototypes had interspersed windows to enable visualization of epicardial structures with ultrasound. Epicardial unipolar ablation and ablation between two electrodes was performed according to protocol (5-60W power, 0-60mls/min irrigation, 78s mean duration).ResultsOf 96 epicardial ablation attempts, unipolar ablation was delivered in 53.1%. Electrogram evidence of ablation, when analyzable, occurred in 75 of 79 (94.9%) therapies. Paired pre/post-ablation pacing threshold (N=74) showed significant increase in pacing threshold post-ablation (0.9 to 2.6mA, P&lt;.0001). Arrhythmias occurred in 18 (18.8%) therapies (11 ventricular fibrillation, 7 ventricular tachycardia), mainly in pigs (72.2%). Coronary artery visualization was variably successful. No phrenic nerve injury was noted during or after ablation. Furthermore, there were minimal pericardial changes with ablation.ConclusionsEpicardial ablation using a partially insulated catheter to confer epicardial directionality and protect the phrenic nerve seems feasible. Iterations with ultrasound windows may enable real-time epicardial surface visualization thus identifying coronary arteries at ablation sites. Further improvements, however, are necessary.

Název v anglickém jazyce

Feasibility of directional percutaneous epicardial ablation with a partially insulated catheter

Popis výsledku anglicky

PurposeTo demonstrate the feasibility of directional percutaneous epicardial ablation using a partially insulated catheter.MethodsPartially insulated catheter prototypes were tested in 12 (6 canine, 6 porcine) animal studies in two centers. Prototypes had interspersed windows to enable visualization of epicardial structures with ultrasound. Epicardial unipolar ablation and ablation between two electrodes was performed according to protocol (5-60W power, 0-60mls/min irrigation, 78s mean duration).ResultsOf 96 epicardial ablation attempts, unipolar ablation was delivered in 53.1%. Electrogram evidence of ablation, when analyzable, occurred in 75 of 79 (94.9%) therapies. Paired pre/post-ablation pacing threshold (N=74) showed significant increase in pacing threshold post-ablation (0.9 to 2.6mA, P&lt;.0001). Arrhythmias occurred in 18 (18.8%) therapies (11 ventricular fibrillation, 7 ventricular tachycardia), mainly in pigs (72.2%). Coronary artery visualization was variably successful. No phrenic nerve injury was noted during or after ablation. Furthermore, there were minimal pericardial changes with ablation.ConclusionsEpicardial ablation using a partially insulated catheter to confer epicardial directionality and protect the phrenic nerve seems feasible. Iterations with ultrasound windows may enable real-time epicardial surface visualization thus identifying coronary arteries at ablation sites. Further improvements, however, are necessary.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

ISSN

1383-875X

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

105-113

Kód UT WoS článku

000444566500013

EID výsledku v databázi Scopus

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